| 查看: 513 | 回复: 2 | |||
| 本帖产生 1 个 翻译EPI ，点击这里进行查看 | |||
[求助]
a为α，b为β生物名词实在看不懂求帮忙
|
|||
|
Based on these facts,Yan et al. [31] reported the microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes-an alter route to 6-methylsteroids. Incubation of 3b-hydroxy-5, 6 a -cyclopropano-5 a -cholestane (6)with Mycobacterium sp. (NRRL B-3805) gave three metabolites, 5,6 a -cyclopropano-5 a -androsta-3, 17-dione (7), 3b-hydroxy-5,6 a -cyclopropano-5 a -androsta-17-one (8) and androsta-4-ene-3,17-dione (5). Fermentation of 3b-hydroxy-5, 6b-cyclopropano-5b- cholestane (9) with Mycobacterium sp. afforded the metabolite 5,5, 6b-cyclopropano-5b-androsta-3, 17-dione (10) and 3 a -hydroxy-5, 6b-cyclopropano-5b-androsta-17-one (11). Similarly, incubationof 3b-hydroxy-5, 6 a -cyclopropano-5 a -cholest-7-ene (12) with Mycobacterium sp. yielded a mixture of side chain cleaved 17-keto steroids as the major products, viz. the cyclopropyl eliminated product 5, 5, 6 a -cyclopropano-5 a -androst-7-ene-3, 17-dione (13), 3b-hydroxy-5, 6 a -cyclopropano-5 a -androst-4-ene-17-one (14), 5, 6 a -cyclopropano-5 a -androst-8(14)-ene-3, 7, 17-trione (15), 5, 6 a -cyclopropano-5 a -androst-8-ene-3, 7, 17-trione (16) and 6 a , 7 a -cyclopropanoandrost-4-ene-3, 17-dione (17) as described in Scheme 2. a为α，b为β |
回复此楼» 猜你喜欢
材料与化工371求调剂
已经有5人回复
-
328分调剂
已经有4人回复
-
295求调剂
已经有7人回复
-
081700，311，求调剂
已经有13人回复
-
283分求调剂
已经有6人回复
-
0854求调剂
已经有3人回复
-
332求调剂
已经有4人回复
-
284求调剂
已经有5人回复
-
304求调剂（085602，过四级，一志愿985）
已经有11人回复
-
0817化学工程与技术求调剂，一志愿中海洋319
已经有10人回复
ssssllllnnnn 
至尊木虫 (知名作家)
Translator and Proofreader
- 翻译EPI: 1690
- 应助: 452 (硕士)
- 金币: 31580.9
- 红花: 100
- 帖子: 7681
- 在线: 19966.6小时
- 虫号: 3328089
- 注册: 2014-07-17
- 专业: 肿瘤发生
【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ★ ...
bxzc123: 金币+100, 翻译EPI+1, ★★★很有帮助 2015-04-23 21:21:54
bxzc123: 金币+100, 翻译EPI+1, ★★★很有帮助 2015-04-23 21:21:54
|
Based on these facts,Yan et al. [31] reported the microbial transformation of 3-hydroxy-5,6-cyclo propano cholestane-an alter route to 6-methyl steroids. Incubation of 3β-hydroxy-5, 6 α-cyclo propano-5 α-cholestane (6)with Mycobacterium sp. (NRRL B-3805) gave three metabolites, 5,6 α-cyclo propano-5 α-androsta-3, 17-dione (7), 3β-hydroxy-5,6 α-cyclo propano-5 α-androsta-17-one (8) and androsta-4-ene-3,17-dione (5). Fermentation of 3β-hydroxy-5, 6β-cyclo propano-5β-cholestane (9) with Mycobacterium sp. afforded the metabolite 5,5, 6β-cyclo propano-5β-androsta-3, 17-dione (10) and 3 α-hydroxy-5, 6β-cyclo propano-5β-androsta-17-one (11). Similarly, incubation of 3β-hydroxy-5, 6 α-cyclo propano-5 α-cholest-7-ene (12) with Mycobacterium sp. yielded a mixture of side chain cleaved 17-keto steroids as the major products, viz. the cyclopropyl eliminated product 5, 5, 6 α-cyclo propano-5 α-androst-7-ene-3, 17-dione (13), 3β-hydroxy-5, 6α-cyclo propano-5α-androst-4-ene-17-one (14), 5, 6 α-cyclo propano-5 α-androst-8(14)-ene-3, 7, 17-trione (15), 5, 6 α-cyclo propano-5 α-androst-8-ene-3, 7, 17-trione (16) and 6α, 7α-cyclo propano androst-4-ene-3,17-dione (17) as described in Scheme 2. 基于这些事实，Yan等【[31】报道的3-羟基-5,6-环丙醇胆甾烷微生物转化为6-甲基类固醇的不同途径。将3β羟基5,6α-环丙醇-5α-胆甾（6）与结核分枝杆菌（NRRL B-3805）孵育，得到3个代谢产物：5,6-α-环丙醇-5α-雄甾3,17二酮（7），3β羟基-5,6-α-环丙醇-5α-雄17酮（8）和雄甾-4-烯-3,17-二酮（5）。3β羟基-5-，6β-环丙醇-5β-胆甾（9）与结核分枝杆菌发酵，得到代谢物5,5，6β-环丙醇-5β-雄甾3,17二酮（10）和3α羟基-5，6β-环丙醇-5β-雄甾-17-酮（11）。类似地，如方案2中所述，3β羟基5,6α-环丙醇-5α-胆甾-7-烯（12）与结核分枝杆菌孵育，得到的主要产物是侧链17-酮类固醇侧链裂解混合物，即环丙基消除产物5，5，6α-环丙醇-5α-雄甾-7-烯-3，17-二酮（13），3β羟基-5，6α-环丙醇-5α-雄-4-烯-17酮（14），5，6α-环丙醇-5α-雄甾-8（14）-烯-3,7，17-三酮（15），5，6α-环丙醇-5-α-雄甾-8-烯-3，7，17三酮（16）和6α，7α-环丙醇，雄-4-烯-3,17-二酮（17）。 |
2楼2015-04-22 21:25:07
3楼2015-04-23 21:22:41
