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Based on these facts,Yan et al. [31] reported the microbial transformation of 3-hydroxy-5,6-cyclopropanocholestanes-an alter route to 6-methylsteroids. Incubation of 3b-hydroxy-5, 6 a -cyclopropano-5 a -cholestane (6)with Mycobacterium sp. (NRRL B-3805) gave three metabolites, 5,6 a -cyclopropano-5 a -androsta-3, 17-dione (7), 3b-hydroxy-5,6 a -cyclopropano-5 a -androsta-17-one (8) and androsta-4-ene-3,17-dione (5). Fermentation of 3b-hydroxy-5, 6b-cyclopropano-5b- cholestane (9) with Mycobacterium sp. afforded the metabolite 5,5, 6b-cyclopropano-5b-androsta-3, 17-dione (10) and 3 a -hydroxy-5, 6b-cyclopropano-5b-androsta-17-one (11). Similarly, incubationof 3b-hydroxy-5, 6 a -cyclopropano-5 a -cholest-7-ene (12) with Mycobacterium sp. yielded a mixture of side chain cleaved 17-keto steroids as the major products, viz. the cyclopropyl eliminated product 5, 5, 6 a -cyclopropano-5 a -androst-7-ene-3, 17-dione (13), 3b-hydroxy-5, 6 a -cyclopropano-5 a -androst-4-ene-17-one (14), 5, 6 a -cyclopropano-5 a -androst-8(14)-ene-3, 7, 17-trione (15), 5, 6 a -cyclopropano-5 a -androst-8-ene-3, 7, 17-trione (16) and 6 a , 7 a -cyclopropanoandrost-4-ene-3, 17-dione (17) as described in Scheme 2. aΪ¦Á£¬bΪ¦Â |
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bxzc123: ½ð±Ò+100, ·ÒëEPI+1, ¡ï¡ï¡ïºÜÓаïÖú 2015-04-23 21:21:54
bxzc123: ½ð±Ò+100, ·ÒëEPI+1, ¡ï¡ï¡ïºÜÓаïÖú 2015-04-23 21:21:54
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Based on these facts,Yan et al. [31] reported the microbial transformation of 3-hydroxy-5,6-cyclo propano cholestane-an alter route to 6-methyl steroids. Incubation of 3¦Â-hydroxy-5, 6 ¦Á-cyclo propano-5 ¦Á-cholestane (6)with Mycobacterium sp. (NRRL B-3805) gave three metabolites, 5,6 ¦Á-cyclo propano-5 ¦Á-androsta-3, 17-dione (7), 3¦Â-hydroxy-5,6 ¦Á-cyclo propano-5 ¦Á-androsta-17-one (8) and androsta-4-ene-3,17-dione (5). Fermentation of 3¦Â-hydroxy-5, 6¦Â-cyclo propano-5¦Â-cholestane (9) with Mycobacterium sp. afforded the metabolite 5,5, 6¦Â-cyclo propano-5¦Â-androsta-3, 17-dione (10) and 3 ¦Á-hydroxy-5, 6¦Â-cyclo propano-5¦Â-androsta-17-one (11). Similarly, incubation of 3¦Â-hydroxy-5, 6 ¦Á-cyclo propano-5 ¦Á-cholest-7-ene (12) with Mycobacterium sp. yielded a mixture of side chain cleaved 17-keto steroids as the major products, viz. the cyclopropyl eliminated product 5, 5, 6 ¦Á-cyclo propano-5 ¦Á-androst-7-ene-3, 17-dione (13), 3¦Â-hydroxy-5, 6¦Á-cyclo propano-5¦Á-androst-4-ene-17-one (14), 5, 6 ¦Á-cyclo propano-5 ¦Á-androst-8(14)-ene-3, 7, 17-trione (15), 5, 6 ¦Á-cyclo propano-5 ¦Á-androst-8-ene-3, 7, 17-trione (16) and 6¦Á, 7¦Á-cyclo propano androst-4-ene-3,17-dione (17) as described in Scheme 2. »ùÓÚÕâЩÊÂʵ£¬YanµÈ¡¾[31¡¿±¨µÀµÄ3-ôÇ»ù-5,6-»·±û´¼µ¨çÞÍé΢ÉúÎïת»¯Îª6-¼×»ùÀà¹Ì´¼µÄ²»Í¬Í¾¾¶¡£½«3¦ÂôÇ»ù5,6¦Á-»·±û´¼-5¦Á-µ¨çÞ£¨6£©Óë½áºË·ÖÖ¦¸Ë¾ú£¨NRRL B-3805£©·õÓý£¬µÃµ½3¸ö´úл²úÎ5,6-¦Á-»·±û´¼-5¦Á-ÐÛçÞ3,17¶þͪ£¨7£©£¬3¦ÂôÇ»ù-5,6-¦Á-»·±û´¼-5¦Á-ÐÛ17ͪ£¨8£©ºÍÐÛçÞ-4-Ï©-3,17-¶þͪ£¨5£©¡£3¦ÂôÇ»ù-5-£¬6¦Â-»·±û´¼-5¦Â-µ¨çÞ£¨9£©Óë½áºË·ÖÖ¦¸Ë¾ú·¢½Í£¬µÃµ½´úлÎï5,5£¬6¦Â-»·±û´¼-5¦Â-ÐÛçÞ3,17¶þͪ£¨10£©ºÍ3¦ÁôÇ»ù-5£¬6¦Â-»·±û´¼-5¦Â-ÐÛçÞ-17-ͪ£¨11£©¡£ÀàËÆµØ£¬Èç·½°¸2ÖÐËùÊö£¬3¦ÂôÇ»ù5,6¦Á-»·±û´¼-5¦Á-µ¨çÞ-7-Ï©£¨12£©Óë½áºË·ÖÖ¦¸Ë¾ú·õÓý£¬µÃµ½µÄÖ÷Òª²úÎïÊDzàÁ´17-ͪÀà¹Ì´¼²àÁ´Áѽâ»ìºÏÎ¼´»·±û»ùÏû³ý²úÎï5£¬5£¬6¦Á-»·±û´¼-5¦Á-ÐÛçÞ-7-Ï©-3£¬17-¶þͪ£¨13£©£¬3¦ÂôÇ»ù-5£¬6¦Á-»·±û´¼-5¦Á-ÐÛ-4-Ï©-17ͪ£¨14£©£¬5£¬6¦Á-»·±û´¼-5¦Á-ÐÛçÞ-8£¨14£©-Ï©-3,7£¬17-Èýͪ£¨15£©£¬5£¬6¦Á-»·±û´¼-5-¦Á-ÐÛçÞ-8-Ï©-3£¬7£¬17Èýͪ£¨16£©ºÍ6¦Á£¬7¦Á-»·±û´¼£¬ÐÛ-4-Ï©-3,17-¶þͪ£¨17£©¡£ |
2Â¥2015-04-22 21:25:07
bxzc123
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3Â¥2015-04-23 21:22:41














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