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2011164112гæ (³õÈëÎÄ̳)
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Whether 3-nitrotyrosine is important in normal cellular processes or is likely to affect specific biological pathways remains unclear. Using GPS-YNO2, a recently described 3-nitrotyrosine prediction algorithm, a set of predictions for nitrated residues in the human proteome was generated. In total, 9.27 per cent of the proteome was predicted to be nitratable (27 922/ 301 091). By matching the predictions against a set of curated and experimentally validated 3-nitrotyrosine sites in human proteins, it was found that GPS-YNO2 is able to predict 73.1 per cent (404/553) of these sites. Furthermore, of these sites, 42 have been shown to be nitrated endogenously, with 85.7 per cent (36/42) of these predicted to be nitrated. This demonstrates the feasibility of using the predicted dataset for a whole proteome analysis. |
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ÖÁ×ðľ³æ (ÖøÃûдÊÖ)
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2011164112: ½ð±Ò+5, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-06-05 13:21:16
2011164112(RXMCDM´ú·¢): ½ð±Ò+5 2015-06-06 18:18:39
RXMCDM: ·ÒëEPI+1 2015-06-06 18:18:44
2011164112: ½ð±Ò+5, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2015-06-05 13:21:16
2011164112(RXMCDM´ú·¢): ½ð±Ò+5 2015-06-06 18:18:39
RXMCDM: ·ÒëEPI+1 2015-06-06 18:18:44
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