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Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in extraribosomal function, persistence, and drug resistance based on transcriptome data,杂志Journal of biomolecular structure & dynamics
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fxysnd: 金币+5, ★★★★★最佳答案 2015-04-20 17:14:49
sunshan4379: LS-EPI+1, 感谢应助! 2015-04-20 17:49:21
Identification of idiosyncratic Mycobacterium tuberculosis ribosomal protein subunits with implications in extraribosomal function, persistence, and drug resistance based on transcriptome data
作者:Fan, XY (Fan, Xiangyu)[ 1 ] ; Tang, XM (Tang, Xiemei)[ 1 ] ; Yan, JL (Yan, Jianlong)[ 1 ] ; Xie, JP (Xie, Jianping)[ 1 ]
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
卷: 32  期: 10  页: 1546-1551
DOI: 10.1080/07391102.2013.826143
出版年: 2014
查看期刊信息
摘要
Ribosome, the protein synthesis machinery essential for all living cells, consists of ribosomal proteins and RNA. Extraribosomal functions have recently been discovered for many ribosomal proteins, acting either as individual regulatory proteins or as a complex with other cell components. However, extraribosomal functions of Mycobacterium tuberculosis ribosomal proteins have not been systematically addressed. To this end, M. tuberculosis ribosomal proteins potentially engaged in extraribosomal functions were curated by data mining from transcriptional profiles of M. tuberculosis exposed to diverse treatments. Six M. tuberculosis ribosomal proteins, namely, S3 (Rv0707, rpsC), L16 (Rv0708, rplP), L29 (Rv0709, rpmC), S17 (Rv0710, rpsQ), S14 (Rv2056c, rpsN2), and L33 (Rv2057c, rpmG1), were found to behave idiosyncratically. The function of these abnormal ribosomal subunits can be further explored. Special emphasis is on their potential value as novel targets for better antibiotics.
关键词
作者关键词:Mycobacterium tuberculosis; ribosomal proteins; extraribosomal function; data mining
KeyWords Plus:GENE-EXPRESSION; ADAPTATION; INSIGHTS
作者信息
通讯作者地址: Xie, JP (通讯作者)
显示增强组织信息的名称        Southwest Univ, Minist Educ Ecoenvironm Three Gorges Reservoir Re, State Key Lab Breeding Base Ecoenviroment & Biore, Key Lab,Sch Life Sci,Inst Modern Biopharmaceut, Chongqing 400700, Peoples R China.
地址:
显示增强组织信息的名称        [ 1 ] Southwest Univ, Minist Educ Ecoenvironm Three Gorges Reservoir Re, State Key Lab Breeding Base Ecoenviroment & Biore, Key Lab,Sch Life Sci,Inst Modern Biopharmaceut, Chongqing 400700, Peoples R China
电子邮件地址:georgex@swu.edu.cn
基金资助致谢
基金资助机构        授权号
National Natural Science Foundation        
81071316
81271882
National Megaprojects for Key Infectious Diseases        
2008ZX10003-006
2012ZX10003-003
New Century Excellent Talents in Universities        
NCET-11-0703
Excellent PhD thesis fellowship of southwest university        
kb2009010
ky2011003
Fundamental Research Funds for the Central Universities        
XDJK2012D011
XDJK2012D007
XDJK2013D003
Natural Science Foundation Project of CQ CSTC        
2010BB5002
查看基金资助信息   
出版商
TAYLOR & FRANCIS INC, 530 CHESTNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
类别 / 分类
研究方向:Biochemistry & Molecular Biology; Biophysics
Web of Science 类别:Biochemistry & Molecular Biology; Biophysics
文献信息
文献类型:Article
语种:English
入藏号: WOS:000340120600003
PubMed ID: 23964652
ISSN: 0739-1102
eISSN: 1538-0254
期刊信息
Impact Factor (影响因子): Journal Citation Reports®
其他信息
IDS 号: AM8JP
Web of Science 核心合集中的 "引用的参考文献": 12
Web of Science 核心合集中的 "被引频次": 0
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入藏号: WOS:000340120600003
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