| 查看: 1162 | 回复: 23 | ||||
| 【奖励】 本帖被评价22次，作者1949stone增加金币 17.6 个 | ||||
[资源]
Applications of microdialysis in pharmaceutical science
|
||||
 Introduction to Applications of Microdialysis in Pharmaceutical Science 1 Tung-Hu Tsai 2 Microdialysis in Drug Discovery 7 Christian Höcht 1. Introduction, 7 2. Phases of Drug Development, 8 3. Role of Biomarkers in Drug Development, 11 4. Role of Pharmacokinetic–Pharmacodynamic Modeling in Drug Development, 12 5. Role of Microdialysis in Drug Development, 15 6. Microdialysis Sampling in the Drug Development of Specifi c Therapeutic Groups, 20 7. Regulatory Aspects of Microdialysis Sampling in Drug Development, 29 8. Conclusions, 30 3 Analytical Considerations for Microdialysis Sampling 39 Pradyot Nandi, Courtney D. Kuhnline, and Susan M. Lunte 1. Introduction, 39 2. Analytical Methodologies, 49 3. Conclusions, 75 v vi CONTENTS 4 Monitoring Dopamine in the Mesocorticolimbic and Nigrostriatal Systems by Microdialysis: Relevance for Mood Disorders and Parkinson’s Disease 93 Giuseppe Di Giovanni, Massimo Pierucci, and Vincenzo Di Matteo 1. Introduction, 93 2. Pathophysiology of Serotonin–Dopamine Interaction: Implication for Mood Disorders, 94 3. Dopamine Depletion in the Nigrostriatal System: Parkinson’s Disease, 109 4. Conclusions, 120 5 Monitoring Neurotransmitter Amino Acids by Microdialysis: Pharmacodynamic Applications 151 Sandrine Parrot, Bernard Renaud, Luc Zimmer, and Luc Denoroy 1. Introduction, 151 2. Monitoring Neurotransmitter Amino Acids by Microdialysis, 152 3. Basic Research on Receptors, 162 4. Psychostimulants and Addictive Drugs, 168 5. Analgesia, 177 6. Ischemia–Anoxia, 182 7. Conclusions and Perspectives, 188 6 Microdialysis as a Tool to Unravel Neurobiological Mechanisms of Seizures and Antiepileptic Drug Action 207 Ilse Smolders, Ralph Clinckers, and Yvette Michotte 1. Introduction, 207 2. Microdialysis to Characterize Seizure-Related Neurobiological and Metabolic Changes in Animal Models and in Humans, 209 3. Microdialysis as a Chemoconvulsant Delivery Tool in Animal Seizure Models, 217 4. Microdialysis Used to Elucidate Mechanisms of Electrical Brain Stimulation and Neuronal Circuits Involved in Seizures, 218 5. Microdialysis Used to Unravel the Mechanisms of Action of Established Antiepileptic Drugs and New Therapeutic Strategies, 219 6. Microdialysis Studies in the Search for Mechanisms of Adverse Effects of Clinically Used Drugs, Drugs of Abuse, and Toxins, 224 7. Combining Microdialysis with Other Complementary Neurotechniques to Unravel Mechanisms of Seizures and Epilepsy, 226 CONTENTS vii 8. The Advantage of Microdialysis Used to Sample Biophase Antiepileptic Drug Levels and to Monitor Neurotransmitters as Markers for Anticonvulsant Activity, 228 9. Microdialysis Used to Study Relationships Between Epilepsy and Its Comorbidities, 236 7 Microdialysis in Lung Tissue: Monitoring of Exogenous and Endogenous Compounds 255 Thomas Feurstein and Markus Zeitlinger 1. Introduction, 255 2. Special Aspects Associated with Lung Microdialysis Compared to Microdialysis in Other Tissues, 255 3. Insertion of Microdialysis Probes into Lung Tissue, 256 4. Insertion of Microdialysis Probes into the Bronchial System, 257 5. Types of Probes, 258 6. Endogenous Compounds, 258 7. Exogenous Drugs, 259 8. Animal Data, 260 9. Clinical Data, 262 10. Comparison of Pharmacokinetic Data in Lung Obtained by Microdialysis and Other Techniques, 264 11. Predictability of Lung Concentrations by Measurements in Other Tissues, 265 8 Microdialysis in the Hepatobiliary System: Monitoring Drug Metabolism, Hepatobiliary Excretion, and Enterohepatic Circulation 275 Yu-Tse Wu and Tung-Hu Tsai 1. Introduction, 275 2. Experimental Considerations of Pharmacokinetic Studies, 279 3. Pharmacokinetic and Hepatobiliary Excretion Studies Employing Microdialysis, 284 4. Conclusions, 287 9 Microdialysis Used to Measure the Metabolism of Glucose, Lactate, and Glycerol 295 Greg Nowak 1. Introduction, 295 2. Glucose, 299 3. Lactate, 301 4. Lactate/Pyruvate Ratio, 303 5. Glycerol, 303 viii CONTENTS 10 Clinical Microdialysis in Skin and Soft Tissues 313 Martina Sahre, Runa Naik, and Hartmut Derendorf 1. Introduction, 313 2. Tissue Bioavailability, 314 3. PK–PD Indices, 323 4. Topical Bioequivalence, 329 5. Endogenous Compounds, 330 6. Conclusions, 331 11 Microdialysis on Adipose Tissue: Monitoring Tissue Metabolism and Blood Flow in Humans 335 Gijs H. Goossens, Wim H. M. Saris, and Ellen E. Blaak 1. Introduction, 335 2. Principles and Practical Considerations in the Use of Microdialysis on Adipose Tissue, 336 3. Use of Microdialysis on Adipose Tissue in Humans, 342 4. Summary and Conclusions, 353 12 Microdialysis as a Monitoring System for Human Diabetes 359 Anna Ciechanowska, Jan M. Wojcicki, Iwona Maruniak-Chudek, Piotr Ladyzynski, and Janusz Krzymien 1. Introduction, 359 2. Monitoring Acute Complications of Diabetes, 362 13 Microdialysis Use in Tumors: Drug Disposition and Tumor Response 403 Qingyu Zhou and James M. Gallo 1. Introduction, 403 2. Microdialysis as a Sampling Technique in Oncology, 404 3. Experimental Considerations, 408 4. Examples of the Use of Microdialysis to Characterize Drug Disposition in Tumor, 414 5. Use of Microdialysis in the Evaluation of Tumor Response to Therapy, 423 6. Conclusions and Future Perspectives, 423 14 Microdialysis Versus Imaging Techniques for In Vivo Drug Distribution Measurements 431 Martin Brunner 1. Introduction, 431 2. Microdialysis, 432 3. Imaging Techniques, 434 4. Magnetic Resonance Imaging and Magnetic Resonance Spectroscopy, 434 CONTENTS ix 5. Positron–Emission Tomography, 435 6. Combination of Microdialysis and Imaging Techniques, 436 7. Summary and Conclusions, 438 15 In Vitro Applications of Microdialysis 445 Wen-Chuan Lee and Tung-Hu Tsai 1. Introduction, 445 2. Microdialysis Used in Culture Systems, 446 3. Microdialysis Used in Enzyme Kinetics, 453 4. Microdialysis Used in Protein Binding, 455 5. Conclusions, 456 16 Microdialysis in Drug–Drug Interaction 465 Mitsuhiro Wada, Rie Ikeda, and Kenichiro Nakashima 1. Introduction, 465 2. Pharmacokinetic Drug–Drug Interaction, 472 3. Pharmacodynamic Drug–Drug Interaction, 487 4. Conclusions, 501 17 Microdialysis in Environmental Monitoring 509 Manuel Miró and Wolfgang Frenzel 1. Introduction, 509 2. In Vivo and In Situ Sampling: Similarities and Differences, 510 3. Critical Parameters Infl uencing Relative Recoveries, 513 4. Detection Techniques, 518 5. Calibration Methods, 519 6. Environmental Applications of Microdialysis, 520 7. Conclusions and Future Trends, 524 INDEX 531 |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : Applications_of_microdialysis_in_pharmaceutical_science.pdf
2015-04-07 23:54:04, 14.56 M
» 收录本帖的淘帖专辑推荐
 药物合成 |
» 猜你喜欢
2026申博推荐
已经有1人回复
-
一篇扩散模型的Nature Machine Intelligence论文和Elsevier上的深度学习药物书籍
已经有1人回复
-
药物学论文润色/翻译怎么收费?
已经有146人回复
-
26考博申请 学or专
已经有15人回复
-
中国药科大学2026入学博士，药物合成和设计经验，放射化学及放射医学研究
已经有25人回复
-
使用MolAICal进行多肽虚拟筛选教程-同样适用于蛋白质和核酸的虚拟筛选
已经有1人回复
-
使用MolAICal计算药物化学过滤器MCFs及MCE-18描述符
已经有0人回复
-
使用MolAICal发现蛋白受体潜在的活性口袋及位点
已经有0人回复
简单回复
2015-04-08 06:52
回复
五星好评 顶一下，感谢分享！
anruoka3楼
2015-04-08 08:54
回复
五星好评 顶一下，感谢分享！
2015-04-08 09:32
回复
五星好评 顶一下，感谢分享！
quietdon5楼
2015-04-08 09:58
回复
五星好评 顶一下，感谢分享！
KUZUTANG6楼
2015-04-08 19:15
回复
五星好评 顶一下，感谢分享！
sjshvdc7楼
2015-04-08 20:44
回复
五星好评 顶一下，感谢分享！
xwj0078楼
2015-04-08 22:05
回复
五星好评 顶一下，感谢分享！
pingshan9楼
2015-04-09 05:18
回复
五星好评 顶一下，感谢分享！
kong16710楼
2015-04-09 13:15
回复
五星好评 顶一下，感谢分享！
maxiaohu11楼
2015-04-09 13:25
回复
五星好评 顶一下，感谢分享！
wtiger12楼
2015-04-09 14:31
回复
五星好评 顶一下，感谢分享！
work03713楼
2015-04-09 18:27
回复
五星好评 顶一下，感谢分享！
qiute62114楼
2015-04-09 20:42
回复
五星好评 顶一下，感谢分享！
kuanghua15楼
2015-04-10 12:40
回复
五星好评 顶一下，感谢分享！
Emerald199016楼
2015-04-10 13:59
回复
五星好评 顶一下，感谢分享！
pumcnsy17楼
2015-05-26 11:22
回复
五星好评 顶一下，感谢分享！
gyzyxy18楼
2015-11-16 14:07
回复
五星好评 顶一下，感谢分享！
Hang201619楼
2017-01-20 14:19
回复
五星好评 顶一下，感谢分享！
Hang201620楼
2017-01-20 14:28
回复
顶一下，感谢分享！
nihaoweiming21楼
2017-01-21 21:37
回复
五星好评 顶一下，感谢分享！
abc7522楼
2017-03-31 22:01
回复
五星好评 顶一下，感谢分享！
TLee23楼
2019-12-07 21:10
回复
五星好评 顶一下，感谢分享！
wanggj12324楼
2020-01-16 17:04
回复
五星好评 顶一下，感谢分享！