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[资源] Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics

1. Principles of Solubility................................................................. 1
Yuchuan Gong, David J.W. Grant, and Harry G. Brittain
2. Ionic Equilibria and the pH Dependence of Solubility ........................ 29
Harry G. Brittain
3. Solvent Systems for Crystallization and Polymorph Selection................. 53
Jonathan M. Miller, Anthony C. Blackburn, Dainius Macikenas, Benjamin M.
Collman, and Na´ .r Rodr´ .guez-Hornedo
4. Solubility Issues in Early Discovery and HTS ..................................... 111
Li Di and Edward H. Kerns
5. Practical Aspects of Solubility Determination in PharmaceuticalPreformulation.......................................................................... 137
Wei-Qin (Tony) Tong
6. Biorelevant Dissolution Media....................................................... 151
Anette M¨ ullertz
7. Selection of Solvent Systems for Membrane-, Cell-, and
Tissue-Based Permeability Assessment ............................................. 179
Franc¸oise Ingels, Anna-Lena Ungell, and Patrick Augustijns
8. The Use of Solubilizing Excipients and Approaches to Generate
Toxicology Vehicles for Contemporary Drug Pipelines ........................ 221
Marcus E. Brewster, Claire Mackie, Ann Lampo, Marc Noppe,and Thorsteinn Loftsson
9. Solubilizing Vehicles for Oral Formulation Development..................... 257
Robert G. Strickley and Reza Oliyai
10. Solubilizing Systems for Parenteral Formulation Development—Small Molecules..................................................... 309
James E. Kipp
11. Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins............................................................... 341
Zahra Shahrokh
12. Non-Aqueous Systems for Formulation Development—Proteins............ 359
Cynthia L. Stevenson
13. Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.............. 403
Adrian Williams
14. Pharmaceutical Solvents for Pulmonary Drug Delivery ........................ 427
Erik Mogalian and Paul Brian Myrdal

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2015-04-06 03:18:19, 4.92 M