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Solvent Systems and Their Selection in Pharmaceutics and Biopharmaceutics
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1. Principles of Solubility................................................................. 1 Yuchuan Gong, David J.W. Grant, and Harry G. Brittain 2. Ionic Equilibria and the pH Dependence of Solubility ........................ 29 Harry G. Brittain 3. Solvent Systems for Crystallization and Polymorph Selection................. 53 Jonathan M. Miller, Anthony C. Blackburn, Dainius Macikenas, Benjamin M. Collman, and Na´ .r Rodr´ .guez-Hornedo 4. Solubility Issues in Early Discovery and HTS ..................................... 111 Li Di and Edward H. Kerns 5. Practical Aspects of Solubility Determination in PharmaceuticalPreformulation.......................................................................... 137 Wei-Qin (Tony) Tong 6. Biorelevant Dissolution Media....................................................... 151 Anette M¨ ullertz 7. Selection of Solvent Systems for Membrane-, Cell-, and Tissue-Based Permeability Assessment ............................................. 179 Franc¸oise Ingels, Anna-Lena Ungell, and Patrick Augustijns 8. The Use of Solubilizing Excipients and Approaches to Generate Toxicology Vehicles for Contemporary Drug Pipelines ........................ 221 Marcus E. Brewster, Claire Mackie, Ann Lampo, Marc Noppe,and Thorsteinn Loftsson 9. Solubilizing Vehicles for Oral Formulation Development..................... 257 Robert G. Strickley and Reza Oliyai 10. Solubilizing Systems for Parenteral Formulation Development—Small Molecules..................................................... 309 James E. Kipp 11. Aqueous Solubilizing Systems for Parenteral Formulation Development—Proteins............................................................... 341 Zahra Shahrokh 12. Non-Aqueous Systems for Formulation Development—Proteins............ 359 Cynthia L. Stevenson 13. Pharmaceutical Solvents as Vehicles for Topical Dosage Forms.............. 403 Adrian Williams 14. Pharmaceutical Solvents for Pulmonary Drug Delivery ........................ 427 Erik Mogalian and Paul Brian Myrdal  |
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