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Malyhon

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As for the RGD-modified film, the surface RGD
peptides could be specifically recognized by integrin receptors
on cell membranes, and thus cells could be anchored to the
surface through a specific ligand-receptor binding. Therefore,
the RGD-modified surface is more favorable to cells than the
NH3 plasma-treated surface. Although the cell viability is similar
on both surfaces, the cells with spindle-like morphology on the
RGD-modified surface are in a better state than those on the
NH3 plasma-treated surface, as shown in Figure 3b,d. The reason
why the RGD-modified surface obtained by our modification
procedure does not show a distinct advantage over the NH3
plasma-treated surface in terms of promoting cell proliferation
is due to the existence of PEG chains, which could resist protein
adsorption and cell adhesion. This partially screens the ability
of RGD-modified surfaces for promoting cell adhesion and
proliferation.

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