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Malyhon

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[求助] 几句论文求大神翻译成中文谢谢

As for the RGD-modified film, the surface RGD
peptides could be specifically recognized by integrin receptors
on cell membranes, and thus cells could be anchored to the
surface through a specific ligand-receptor binding. Therefore,
the RGD-modified surface is more favorable to cells than the
NH3 plasma-treated surface. Although the cell viability is similar
on both surfaces, the cells with spindle-like morphology on the
RGD-modified surface are in a better state than those on the
NH3 plasma-treated surface, as shown in Figure 3b,d. The reason
why the RGD-modified surface obtained by our modification
procedure does not show a distinct advantage over the NH3
plasma-treated surface in terms of promoting cell proliferation
is due to the existence of PEG chains, which could resist protein
adsorption and cell adhesion. This partially screens the ability
of RGD-modified surfaces for promoting cell adhesion and
proliferation.

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1楼 2015-03-27 13:08:55

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jiangguofeng

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专业: 合成药物化学

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Malyhon: 金币+9, ★★★★★最佳答案 2015-03-29 12:13:51

就RGD修饰膜而言,表面RGD缩氨酸可以通过细胞膜上整合素受体进行特异性识别,从而细胞可以通过特定的配体-受体结合固定到该表面。所以RGD修饰表面要比NH3表面对细胞更为有利。尽管细胞成活力在两个表面上都是相似的,但是在RGD修饰的表面上的纺锤-状细胞形态与那些在NH3等离子体处理过的表面上的相比较处于一个更好的状态,如图3b,d所示。就促进细胞增殖而言，之所以通过我们的修饰方法得到的RGD-修饰表面没有显示出比NH3等离子体处理过的表面具有明显优势，是由于PEG链的存在,这会抵抗蛋白质吸附和细胞粘附。对RGD修饰的表面的能力进行部分地筛选以促进细胞粘附力和繁殖。

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