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      Ä¿Ç°CTIÖ÷Òª¶¼ÊÇ˵PacritinibµÄ°²È«ÐԺã¬ÎÞѪС°å¼ÆÊý½µµÍºÍƶѪ£¨ ruxolitinib×î³£¼ûѪҺѧ²»Á¼·´Ó¦(·¢ÉúÂÊ > 20%)ÊÇѪС°å¼ÆÊý¼õµÍºÍƶѪ£©¡£Pacritinib¸¹Ðº¡¢¶ñÐĺÍŻͲ»Á¼·´Ó¦¸ß£¬Adam FeuersteinÈÏΪÕâЩ賦µÀ²»Á¼·´Ó¦»áÓ°Ïì×ÜÌåÁÆÐ§£¬¶øÇÒÈÏΪÄÜ»ñµÃµÄÊг¡±È½ÏС£¬Ö»ÓÐÇøÇøÑªÐ¡°å¼ÆÊýµÄµÍ»¼ÕߺͲ»ÄÍÊܵϼÕß[4]£¬Òò´Ë¾¡¹ÜͶ×ÊÕß¿´ºÃCTI»á³ÉΪµÚÒ»¸ö´òÆÆµÄ¸Ã¹æÔòµÄ¹«Ë¾£¬µ«ÊÇAdam FeuersteinÒÔFeuerstein-Ratain¹æÔòÈÏΪCTI°Ù·Ö°Ùʧ°Ü¡£³§¼ÒºÜÉÙ˵ÓÐЧÐÔµÄÎÊÌ⣬¹À¼ÆÒ²ºÃ²»µ½ÄÇÀïÈ¥¡£¹ûÈ»PacritinibµÄ2ÆÚÁÙ´²Ö÷ÒªÖÕµãÏÔʾ£¬Ö»ÓÐ24%µÄ»¼Õߵį¢Ìå»ýÖÁÉÙ¼õС 35%[6]£¬ÓÐЧÐÔÓëÉϱ߼¸¸öÒ©ÎïÕæµÄûÓÐÓÅÊÆ¡£ÖÁÓÚ3ÆÚÁÙ´²µÄÊý¾Ý£¬¹À¼ÆÒ²ºÃ²»µ½ÄÄÀïÈ¥£¬¼´Ê¹Åú×¼ÏúÁ¿ÔÚ¼¤ÁҵľºÕùÖÐÒ²ÊǼ¦ÀßµÄÊг¡·Ý¶î¡£
http://weibo.com/p/1005052111021604/wenzhang


[1] doi:10.1007/s10822-012-9572-z
[2]doi:10.1021/jm200326p
[3]http://www.medscape.com/viewarticle/769960?src=rss
[4]http://www.pmlive.com/pharma_news/ash_meeting_hears_of_progress_with_myelofibrosis_drugs_454235
[5]http://www.thestreet.com/story/12286892/1/biotech-stock-mailbag-cell-therapeutics-and-the-ariad-hostile-react-o-meter-meltdown.html
[6]http://www.prnewswire.com/news-releases/sbios-novel-jak2-inhibitor-pacritinib-sb1518-effectively-reduces-splenomegaly--in-myelofibrosis-mf-patients-with-minimal-impact-on-existing-cytopenias-providing-important-therapeutic-niche-in-treatment-of-mf-135443383.html
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