| 查看: 278 | 回复: 3 | ||
| 当前主题已经存档。 | ||
| 【悬赏金币】回答本帖问题，作者LUOLIYIBIN将赠送您 10 个金币 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
[求助]
10金币求摘要翻译，急！
|
||
|
注意：请不要用在线翻译，希望能逐句翻译，语法要正确，谢谢！ 【有效期至2008年5月29日】 巴氯芬(Baclofen)，是γ-氨基丁酸的取代衍生物,曾作为肌松药用于临床，近年来又发现了许多新的应用.本实验通过总结以前制备巴氯芬的经验，找出一条新的制备途径。 制备方法：将对氯苯甲醛与丙二酸二乙酯用三乙胺作催化剂缩合生成对氯代苯亚甲基-双-乙酰乙酸乙酯，在氢氧化钠溶液中加热水解得对氯代苯基戊二酸,用乙酐脱水环合生成对氯代苯基戊二酸酐，再用浓氨水胺化生成对氯代苯基戊二酸单酰胺，最后于碱性溶液中滴加次氯酸钠，经Hofmann降解制得巴氯芬。 该合成工艺具有原料易得、反应条件温和、操作简便等优点，从而节省了原料、降低了成本并缩短了反应周期。 [ Last edited by LUOLIYIBIN on 2008-5-28 at 17:22 ] |
回复此楼» 猜你喜欢
277求调剂
已经有23人回复
-
322求调剂，08工科
已经有4人回复
-
材料工程281还有调剂机会吗
已经有30人回复
-
化学070300 求调剂
已经有16人回复
-
化工学硕294分，求导师收留
已经有12人回复
-
一志愿哈工大 085600 277 12材科基求调剂
已经有32人回复
-
268分085602化学工程调剂
已经有31人回复
-
一志愿安大生物学07初试322、本科二本、调剂求助
已经有11人回复
-
食品与营养（0955）271求调剂
已经有7人回复
-
085600材料与化工349分求调剂
已经有9人回复
4楼2008-05-28 16:03:13
|
Baclofen (Baclofen), γ-aminobutyric acid is the replacement derivatives, as a muscle relaxant drugs have been used in clinical, in recent years discovered many new applications. This study prepared by summing up past experience baclofen, to find Preparation to a new way. Preparation:-chlorobenzaldehyde and the MDA will Diethyl with triethylamine catalyst for the condensation on the formation of benzene methylene chloride - double - Ethylacetoacetate, sodium hydroxide solution heating hydrolysis The chlorinated phenyl glutaric acid, acetic anhydride dehydration with a generation of chloro phenyl glutaric acid anhydride, and then concentrated on the production of ammonia amine chlorinated phenyl glutaric acid amide, the last in alkaline solution In dropping sodium hypochlorite, as Hofmann degradation system in the baclofen. Synthesis of the raw materials are easily obtained, the mild reaction conditions, easy to operate, and other advantages, saving raw materials and reduce the cost and shorten the reaction cycle. |
2楼2008-05-28 15:56:05
3楼2008-05-28 15:57:05
