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hanbing7525银虫 (小有名气)
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Native C3 itself is biologically inactive. C3 is derived by proteolytic processing of a single-chain proC3 precursor to and -chains (Fig. 1A). C3 contains eight MG (macroglobulin) domains that form a key ring, with MG1–4 completing one ring,MG5 and MG6 forming a second, overlapping half-ring, and MG7 and MG8 extending the second half-ring . The C345C domain forms a knob-like protrusion (Fig. 1B). The TED is inserted in the CUB domain, which in turn is inserted between MG domains 7 and 8 (Fig. 1 A and B). The reactive thioester bond is shielded from solvent within the interface of the TED with the MG8 domain (Fig. 1B). EM revealed three different groups (I–III) of C3 class averages with different orientations on the grid (Fig. 2 A Lower), which show excellent cross-correlation with projections from the crystal structure (Fig. 3 A–C). The domains in C3 are most clearly visible in the group II orientation (Fig. 3B, compare with Fig. 1B). |
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weichao123
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爱与雨下: 金币+1 2015-01-02 09:27:53
hanbing7525(RXMCDM代发): 金币+40, 多谢应应助！ 2015-02-01 08:56:26
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爱与雨下: 金币+1 2015-01-02 09:27:53
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???C3???????????????? C3?????????PROC3??????????????-chains ???1A?????á? C3???????MG???????? ?γ????????????MG1a ? ??4?????????? MG5??MG6?γ????????????? MG7??MG8??????????? ????C345C???γ????????????1B?? ????TED????CUB????????????MG??7??8 ???1 A??B??????????????????????????ε?TED??MG8???1B?????????? EM?????????????????C3????????????????????2?????????????????????????????????????????????? ???3??AA ???IA ? ?????C ?? ????C3?е???????????????????????????3B?У???????1B?? ?? |
3楼2014-12-31 15:26:14
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爱与雨下: 金币+1 2015-01-02 09:28:04
hanbing7525(RXMCDM代发): 金币+10, 多谢应助！ 2015-02-01 08:56:07
爱与雨下: 金币+1 2015-01-02 09:28:04
hanbing7525(RXMCDM代发): 金币+10, 多谢应助！ 2015-02-01 08:56:07
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原始的C3无生物活性。C3由proC3单链前驱体水解为多连时得到（图1A）。C3含八个巨球蛋白，形成了钥匙链，其中MG1–4为一环、MG5及MG6为重叠第二环，而MG7及MG8重叠为另半环。C345C域形成了瘤状突起。（图1B） 将TED插入CUB域中，而CUB则插入于MG域7与8之间（图1A及1B）。将活性硫脂链与TED及MG8界面中的溶剂相隔离（图1B）。 （翻译了一部分，太专业了，不知道你们的"行话"   |
2楼2014-12-19 11:05:33
