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德国神经退行性疾病研究中心DZNE情况介绍 已有11人参与
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德国神经退行性疾病研究中心DZNE是2006年新成立的一个联邦政府科研中心,现分散于德国的9个城市,共有人员近600人,主要研究方向包括各种重大老年神经退行性疾病: Alzheimer’s Disease Parkinson’s Disease Frontotemporal Dementia Multiple System Atrophy Progressive Supranuclear Palsy Amyotrophic Lateral Sclerosis Huntington’s Disease Spinocerebellar Ataxias Hereditary Spastic Paraplegias 科研定位是: • Understand causes and mechanisms of neurodegenerative disease • Develop new strategies for their prevention and treatment • Improve care and quality of life for patients and families 所面对的科研挑战是: • Mechanisms of disease pathogenesis (and, indeed, many aspects of normal brain physiology) are not well-understood • Most cases of human disease caused by complex gene-environment interactions on a background of aging • Diseases tend to be slowly progressive; diagnosis is late and imprecise • Good experimental models of disease are lacking 基础研究的重点是: Priority Areas: 1. Identify determinants of normal neuronal physiology and survival 2. Define mechanisms of disease • Protein misfolding and spreading • Risk factors • Inflammation • Synaptic and network dysfunction 3. Discovery of new drug targets and candidates 4. Development of new disease models 5. Determine drivers of neuronal recovery and neurogenesis 临床研究的重点是: Priority Areas: 1. Early diagnosis and course prediction • e.g. functional brain imaging, EEG/MEG mapping of brain network activity and encoding of memory, novel cognitive and spatial navigational assessment tools 2. Disease etiology and biomarkers • e.g. patient-derived iPS cell analytics, epigenetic dysregulation, inflammation biomarkers, exosomal fingerprints 3. Prevention, resilience and therapy • e.g. cognitive and physical activity training paradigms, transcranial oscillatory brain stimulation, drug trials |
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2014-12-14 10:15:02, 997.86 K
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