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专业: 凝聚态物性 II ：电子结构
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[交流] 德国神经退行性疾病研究中心DZNE情况介绍已有11人参与

德国神经退行性疾病研究中心DZNE是2006年新成立的一个联邦政府科研中心，现分散于德国的9个城市，共有人员近600人，主要研究方向包括各种重大老年神经退行性疾病：
Alzheimer’s Disease
Parkinson’s Disease
Frontotemporal Dementia
Multiple System Atrophy
Progressive Supranuclear Palsy
Amyotrophic Lateral Sclerosis
Huntington’s Disease
Spinocerebellar Ataxias
Hereditary Spastic Paraplegias
科研定位是：
• Understand causes and mechanisms of neurodegenerative disease
• Develop new strategies for their prevention and treatment
• Improve care and quality of life for patients and families
所面对的科研挑战是：
• Mechanisms of disease pathogenesis (and, indeed, many aspects of normal brain physiology) are not well-understood
• Most cases of human disease caused by complex gene-environment interactions on a background of aging
• Diseases tend to be slowly progressive; diagnosis is late and imprecise • Good experimental models of disease are lacking
基础研究的重点是：
Priority Areas:
1. Identify determinants of normal neuronal physiology and survival
2. Define mechanisms of disease
• Protein misfolding and spreading
• Risk factors
• Inflammation
• Synaptic and network dysfunction
3. Discovery of new drug targets and candidates
4. Development of new disease models
5. Determine drivers of neuronal recovery and neurogenesis
临床研究的重点是：
Priority Areas:
1. Early diagnosis and course prediction
• e.g. functional brain imaging, EEG/MEG mapping of brain network activity and encoding of memory, novel cognitive and spatial navigational assessment tools
2. Disease etiology and biomarkers
• e.g. patient-derived iPS cell analytics, epigenetic dysregulation, inflammation biomarkers, exosomal fingerprints
3. Prevention, resilience and therapy
• e.g. cognitive and physical activity training paradigms, transcranial oscillatory brain stimulation, drug trials

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