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µÂ¹úÉñ¾ÍËÐÐÐÔ¼²²¡Ñо¿ÖÐÐÄDZNEÊÇ2006ÄêгÉÁ¢µÄÒ»¸öÁª°îÕþ¸®¿ÆÑÐÖÐÐÄ£¬ÏÖ·ÖÉ¢Óڵ¹úµÄ9¸ö³ÇÊУ¬¹²ÓÐÈËÔ±½ü600ÈË£¬Ö÷ÒªÑо¿·½Ïò°üÀ¨¸÷ÖÖÖØ´óÀÏÄêÉñ¾ÍËÐÐÐÔ¼²²¡£º Alzheimer¡¯s Disease Parkinson¡¯s Disease Frontotemporal Dementia Multiple System Atrophy Progressive Supranuclear Palsy Amyotrophic Lateral Sclerosis Huntington¡¯s Disease Spinocerebellar Ataxias Hereditary Spastic Paraplegias ¿ÆÑж¨Î»ÊÇ£º • Understand causes and mechanisms of neurodegenerative disease • Develop new strategies for their prevention and treatment • Improve care and quality of life for patients and families ËùÃæ¶ÔµÄ¿ÆÑÐÌôÕ½ÊÇ£º • Mechanisms of disease pathogenesis (and, indeed, many aspects of normal brain physiology) are not well-understood • Most cases of human disease caused by complex gene-environment interactions on a background of aging • Diseases tend to be slowly progressive; diagnosis is late and imprecise • Good experimental models of disease are lacking »ù´¡Ñо¿µÄÖØµãÊÇ£º Priority Areas: 1. Identify determinants of normal neuronal physiology and survival 2. Define mechanisms of disease • Protein misfolding and spreading • Risk factors • Inflammation • Synaptic and network dysfunction 3. Discovery of new drug targets and candidates 4. Development of new disease models 5. Determine drivers of neuronal recovery and neurogenesis ÁÙ´²Ñо¿µÄÖØµãÊÇ£º Priority Areas: 1. Early diagnosis and course prediction • e.g. functional brain imaging, EEG/MEG mapping of brain network activity and encoding of memory, novel cognitive and spatial navigational assessment tools 2. Disease etiology and biomarkers • e.g. patient-derived iPS cell analytics, epigenetic dysregulation, inflammation biomarkers, exosomal fingerprints 3. Prevention, resilience and therapy • e.g. cognitive and physical activity training paradigms, transcranial oscillatory brain stimulation, drug trials |
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