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（1） Wang Xiujun, Ming-Li Yang, Lan-Ping Zhang, Tong Yao, Yin Wang, Jie Wu. Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents. Chin. Chem. Lett. 25(2014)589-592 请把检索页面，下载pdf版本，并发送给我。 谢谢 邮箱sunhw_hit@126.com |
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Paulwolf
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6楼2014-12-12 16:20:32
Paulwolf
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Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents 作者:Wang, XJ (Wang, Xiu-Jun)[ 1,2 ] ; Yang, ML (Yang, Ming Li)[ 2 ] ; Zhang, LP (Zhang, Lan-Ping)[ 2 ] ; Yao, T (Yao, Tong)[ 1,2 ] ; Chen, C (Chen, Cheng)[ 2 ] ; Mao, LG (Mao, Lian-Gang)[ 1,2 ] ; Wang, Y (Wang, Yin)[ 2 ] ; Wu, J (Wu, Jie)[ 3 ] CHINESE CHEMICAL LETTERS 卷: 25 期: 4 页: 589-592 DOI: 10.1016/j.cclet.2014.01.019 出版年: APR 2014 查看期刊信息 摘要 A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 关键词 作者关键词:Bis-benzimidazole; Anti-tumor; DNA minor groove KeyWords Plus:ANTITUMOR 作者信息 通讯作者地址: Yang, ML (通讯作者) JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China. 地址: [ 1 ] 716th Inst CSIC, Lianyungang 222006, Peoples R China [ 2 ] JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China [ 3 ] Wuhan Bioengn Inst, Dept Pharmaceut Engn, Wuhan 430415, Peoples R China 电子邮件地址:Ymlwxj@126.com; tomson-wu@foxmail.com 基金资助致谢 基金资助机构 授权号 Wuhan City Department of Education 20091(106) 查看基金资助信息 出版商 ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Multidisciplinary 文献信息 文献类型:Article 语种:English 入藏号: WOS:000335108000024 ISSN: 1001-8417 电子 ISSN: 1878-5964 其他信息 IDS 号: AG0LW Web of Science 核心合集中的 "引用的参考文献": 14 Web of Science 核心合集中的 "被引频次": 0 |
2楼2014-12-12 16:15:25
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Design of novel bis-benzimidazole derivatives as DNA minor groove binding agents 作者:Wang, XJ (Wang, Xiu-Jun)[ 1,2 ] ; Yang, ML (Yang, Ming Li)[ 2 ] ; Zhang, LP (Zhang, Lan-Ping)[ 2 ] ; Yao, T (Yao, Tong)[ 1,2 ] ; Chen, C (Chen, Cheng)[ 2 ] ; Mao, LG (Mao, Lian-Gang)[ 1,2 ] ; Wang, Y (Wang, Yin)[ 2 ] ; Wu, J (Wu, Jie)[ 3 ] CHINESE CHEMICAL LETTERS 卷: 25 期: 4 页: 589-592 DOI: 10.1016/j.cclet.2014.01.019 出版年: APR 2014 查看期刊信息 摘要 A new series of bis-benzimidazole derivatives were designed and synthesized. In vitro cytotoxicity evaluation showed that these compounds exhibited high activity against the selected tumor cells. Among them, compound 9 owned the best potential, its IC50 values being 5.95 mu mol/L (mononuclear tumor cell line (U937)) and 5.58 mu mol/L (cervical cancer cell (HeLa)). Fluorescence and UV-vis studies showed that compound 9 could bind into the minor groove of DNA. (C) 2014 Ming-Li Yang. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved. 关键词 作者关键词:Bis-benzimidazole; Anti-tumor; DNA minor groove KeyWords Plus:ANTITUMOR 作者信息 通讯作者地址: Yang, ML (通讯作者) JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China. 地址: [ 1 ] 716th Inst CSIC, Lianyungang 222006, Peoples R China [ 2 ] JARI Pharmaceut Co Ltd, Lianyungang 222006, Peoples R China [ 3 ] Wuhan Bioengn Inst, Dept Pharmaceut Engn, Wuhan 430415, Peoples R China 电子邮件地址:Ymlwxj@126.com; tomson-wu@foxmail.com 基金资助致谢 基金资助机构 授权号 Wuhan City Department of Education 20091(106) 查看基金资助信息 出版商 ELSEVIER SCIENCE INC, 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Multidisciplinary 文献信息 文献类型:Article 语种:English 入藏号: WOS:000335108000024 ISSN: 1001-8417 电子 ISSN: 1878-5964 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: AG0LW Web of Science 核心合集中的 "引用的参考文献": 14 Web of Science 核心合集中的 "被引频次": 0 |
3楼2014-12-12 16:16:14
sunhw_hit
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4楼2014-12-12 16:16:38
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