| 查看: 270 | 回复: 1 | |||
| 【奖励】 本帖被评价1次，作者Abbytan增加金币 0.8 个 | |||
[资源]
Preparation, structural analysis, and properties of tenoxicam cocrystals
|
|||
|
找了好久替诺昔康晶型的文献资料，终于被我找到啦，哈哈。 Preparation, structural analysis, and properties of tenoxicam cocrystals Jagdishwar R. Patela,c, Robert A. Q1 Carltonb, Thomas E. Needhamc, Clinton O. Chichesterc, Frederick G. Vogtb, a b s t r a c t Cocrystals of tenoxicam, a non-steroidal anti-inflammatory drug, are screened, prepared, and characterized in this study. Nine tenoxicam cocrystals were identified using solvent-drop grinding (SDG) techniques. Structural characterization was performed using powder X-ray diffraction (PXRD), differential scanning calorimetry, and multinuclear solid-state NMR (SSNMR). Thermal analysis, PXRD, and 1D SSNMR are used to detect solvates and phase mixtures encountered in SDG cocrystal screening. 2D SSNMR methods are then used to confirm cocrystal formation and determine structural aspects for selected cocrystals formed with saccharin, salicylic acid, succinic acid, and glycolic acid in comparison to Forms I and III of tenoxicam. Molecular association is demonstrated using cross-polarization heteronuclear dipolar correlation (CP-HETCOR) methods involving 1H and 13C nuclei. Short-range 1H–13C CP-HETCOR and 1H–1H double-quantum interactions between atoms of interest, including those engaged in hydrogen bonding, are used to reveal local aspects of the cocrystal structure. 15N SSNMR is used to assess ionization state and the potential for zwitterionization in the selected cocrystals. The tenoxicam saccharin cocrystal was found to be similar in structure to a previously-reported cocrystal of piroxicam and saccharin. The four selected cocrystals yielded intrinsic dissolution rates that were similar or reduced relative to tenoxicam Form III. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 201283135122.pdf
2014-12-05 17:14:04, 2.01 M
» 猜你喜欢
己酮可可碱过氧化杂质限度
已经有2人回复
-
求助Isoeugenol质量标准
已经有0人回复
-
药理学论文润色/翻译怎么收费?
已经有170人回复
-
Gliclazide
已经有0人回复
-
塞替派/噻替哌（Thiotepa） 质量控制
已经有16人回复
-
有没有大佬可以帮忙查下Trijardy XR和Qternmet XR历年销售数据呀
已经有0人回复
-
酰胺水解求助
已经有11人回复
-
中药材标准目录大全llp2026（含各省市中药材和炮制规范）
已经有0人回复
-
酰胺脱乙酰基
已经有13人回复
-
见刊快的中文核心期刊
已经有1人回复
简单回复
tony_min2楼
2015-06-29 11:47
回复
五星好评 顶一下，感谢分享！