| 查看: 287 | 回复: 1 | ||
| 【奖励】 本帖被评价1次，作者Abbytan增加金币 0.8 个 | ||
[资源]
Preparation, structural analysis, and properties of tenoxicam cocrystals
|
||
|
找了好久替诺昔康晶型的文献资料，终于被我找到啦，哈哈。 Preparation, structural analysis, and properties of tenoxicam cocrystals Jagdishwar R. Patela,c, Robert A. Q1 Carltonb, Thomas E. Needhamc, Clinton O. Chichesterc, Frederick G. Vogtb, a b s t r a c t Cocrystals of tenoxicam, a non-steroidal anti-inflammatory drug, are screened, prepared, and characterized in this study. Nine tenoxicam cocrystals were identified using solvent-drop grinding (SDG) techniques. Structural characterization was performed using powder X-ray diffraction (PXRD), differential scanning calorimetry, and multinuclear solid-state NMR (SSNMR). Thermal analysis, PXRD, and 1D SSNMR are used to detect solvates and phase mixtures encountered in SDG cocrystal screening. 2D SSNMR methods are then used to confirm cocrystal formation and determine structural aspects for selected cocrystals formed with saccharin, salicylic acid, succinic acid, and glycolic acid in comparison to Forms I and III of tenoxicam. Molecular association is demonstrated using cross-polarization heteronuclear dipolar correlation (CP-HETCOR) methods involving 1H and 13C nuclei. Short-range 1H–13C CP-HETCOR and 1H–1H double-quantum interactions between atoms of interest, including those engaged in hydrogen bonding, are used to reveal local aspects of the cocrystal structure. 15N SSNMR is used to assess ionization state and the potential for zwitterionization in the selected cocrystals. The tenoxicam saccharin cocrystal was found to be similar in structure to a previously-reported cocrystal of piroxicam and saccharin. The four selected cocrystals yielded intrinsic dissolution rates that were similar or reduced relative to tenoxicam Form III. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : 201283135122.pdf
2014-12-05 17:14:04, 2.01 M
» 猜你喜欢
292药学调剂
已经有1人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有0人回复
-
药理学论文润色/翻译怎么收费?
已经有169人回复
-
锦州医科大学药用生物材料（专业代码1007Z1）招收调剂考生
已经有2人回复
-
26申博自荐
已经有12人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
SUES&NERCN课题组接受硕士生调剂 (学硕1名+专硕1名)
已经有0人回复
-
药物检测中微生物限度计数结果判断
已经有0人回复
-
申博自荐
已经有2人回复
-
求大佬收留
已经有0人回复
简单回复
tony_min2楼
2015-06-29 11:47
回复
五星好评 顶一下，感谢分享！