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Several polymers have been used to fabricate porous scaffolds for three-dimensional cell or tissue culture to repair bone defect,including poly (L-lactic-co-glycolic acid)(PLGA). It is one of the most widely used biodegradable polymers because of its good biocompatibility and regulable degradation rate which can be readily modulated by varying the copolymer ratio of lactic to glycolic acid [1]. Several methods have been adopted to fabricate porous biodegradable PLGA scaffold, including solvent casting/ particulate leaching [2,3], phase separation [4,5], emulsion freezedrying[6], gas foaming [7,8], electrospun [9], 3-D printing [10],fiber bonding [11] and microspheres sintering [12¨C15]. An ideal scaffold is supposed to bear the characteristics of excellent biocompatibility, cytocompatibility, controllable biodegradability,suitable microstructure (pore size and porosity) and mechanical properties [16,17]. Poly (b-hydroxybutyrate-co-b-hydroxyvalerate) (PHBV) copolymers,especially PHBV with 8% HV component have drawn many attention, owing to its low cytotoxicity and cell compatibility [18].Chen et al. have studied the interactions between PHBV and human keratinocytes [19], allogeneic chondrocytes [20], glial cells [21],fibroblast and osteoblast [22], and these studies proved that PHBV can support the above cells to adhere and proliferate. In addition,PHBV matrices have been proved to support fibroblast proliferation while maintaining the structural integrity [23]. When PHBV was used as sutures, it did not bring about acute inflammation, necrosis or malignant tumor within 1 year [24,25]. |
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