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However, the use of copper(II) salts as anticancer drugs presents some drawbacks, which are mainly related to their toxicity and relatively poor bioavailability. To overcome these limitations, copper(II) complexes of multidentate chelate ligands have been evaluated in recent years as alternatives to simple copper salts. In this paper, we report the synthesis of several new copper(II) complexes of various amino acid-derived Schiff base ligands. It is well known that 5-Fluorouracil (5-FU) remains the most commonly used anticancer drug for the treatment of solid tumors, although objective response rates are as low as 20%. Biological activity data showed that the complexes obtained in this study were more cytotoxic than 5-FU against tumor cell lines.  5.jpg |
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篮球少年: 金币+12, 翻译EPI+1, ★★★★★最佳答案, 很不错 2014-11-20 17:44:30
篮球少年: 金币+12, 翻译EPI+1, ★★★★★最佳答案, 很不错 2014-11-20 17:44:30
| 然而，使用铜（II）盐作为抗肿瘤药物存在一些缺点，主要与它们的毒性和生物利用度比较差有关。为克服这些限制，近年来，作为简单铜盐的替代物，已经对多齿螯合配位体铜（II）配合物进行了评价。在本文中，我们报道的各种氨基酸衍生的席夫碱配体的几种新铜（II）配合物的合成。众所周知，5-氟尿嘧啶（5-FU）仍然是用于治疗实体瘤的最常用抗癌药物，虽然客观应答率低达20％。生物活性数据表明，在本研究中得到的复合物在抗肿瘤细胞系中比5-FU的细胞毒性更大。 |
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