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ÎÄÏ×Êǽ²×ª»ùÒòСÊóÄ£ÐÍ£¬ÀïÃæÓÐÒ»¶Î»°¡°In brief, genetically humanized mouse models can be generated by randomly inserting a human expression vector into the mouse genome, by introducing a freely segregating mouse or human artificial chromosome (MAC or HAC) or by a targeted integration at a predefined position. these approaches can be combined either with or without a deletion of the corresonding murine gene(s). expression of the human transgene can be driven off a heterologous promoter, the corresponding mouse promoter or the congnate human promoter." ÏëÎÊÏÂheterologous promoter, the corresponding mouse promoter or the congnate human promoterÈý¸ö·Ö±ðÖ¸µÄʲôÒâ˼¡£Ã»Óлù´¡£¬Ï£ÍûÄܽ²µÄ¼òµ¥µã£¬²»ÓøßÉîµÄ£¬¿ÆÆÕÐÔÖʵľÍÐÐÁË£¬Ð»Ð»¡£ |
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- ×¢²á: 2013-11-27
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