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All rats were randomly divided into three groups (n=18). Pretreatment group(group P): mSNA (modified spinal never ligation) rats were gavaged with minocycline (3mg/100g) through mouth one hour before mSNA rats perparation . Control group(group C): mSNA rats were gavaged with equivalent saline through mouth one hour before mSNA rats perparation . Sham group(group S): the rats were exposed the right L4¡¢L5 spinal never but not ligated, gavaged with equivalent saline through mouth one hour before animal preparation. According to different observation time, each group was subdivided into three groups: the1st¡¢4th¡¢7th days postoperative subgroups(n=6). ´ÆÐÔSD´óÊó54Ö»£¬Ëæ»ú·Ö³É3´ó×飨n=18£©£º£¨1£©Ô¤´¦Àí×飨P×é)£¬mSNAÄ£ÐÍÖÆ±¸Ç°1Сʱ¾¿Ú¹àθ¶þ¼×°·ËÄ»·ËØ(3mg/100g)£»£¨2£©¶ÔÕÕ×飨C×飩£¬mSNAÄ£ÐÍÖÆ±¸Ç°1Сʱ¾¿Ú¹àθµÈÁ¿ÉúÀíÑÎË®£»£¨3£©¼ÙÊÖÊõ×é(S×飩£¬ÖƱ¸Ç°1Сʱ¾¿Ú¹àθÉúÀíÑÎË®²¢±©Â¶ÓÒ²àL4¡¢L5¼¹Éñ¾µ«²»½áÔú¡£´ó×鶯ÎïÓÖ¸ù¾Ý¹Û²ìʱ¼äÓÖ·ÖΪÊõºó1¡¢4¡¢7ÌìÈý¸öÑÇ×飨n=6), |
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Sham group(group S): the rats were exposed the right L4¡¢L5 spinal never but not ligated, gavaged with equivalent saline through mouth one hour before animal prepreparation. ÎÒ¾õµÃд³É Sham group(group S):the rats were gavaged with equivalent saline through mouth one hour before animal prepreparation£¬with their right L4¡¢L5 spinal nerve exposed but not ligated. ÎҸоõÕâÑùд¸üºÃЩ.Ô¾äÖиоõÓеãÖÐʽӢÓïµÄζµÀ¡£ ˵µÄ²»¶ÔµÄµØ·½Çë¼ûÁ |
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