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| The conclusion that TNF¦Áis a trigger of spontaneous pain, also be proved with minocycline preoperative in mSNA rats. Because the TNF¦Áexpression was suppressed in mSNA rats with minocycline preoperative. As we known, minocycline is a strong anti-inflammatory drug. Minocycline can significantly suppress macrophages recruitment, microglial activation [39], inflammatory cytokines releasing. Thus it can suppress TNF¦Áexpressing in the spinal dorsal horn of mSNA rats in our studying. And the SFL behavior was alleviated too. Our result is also consistent with Ik-Hyun Cho report that the SFL behavior is suppressed with minocycline pre-surgery in the inflammatory pain rats [14]. |
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- ½ð±Ò: 107
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- ³æºÅ: 553271
- ×¢²á: 2008-05-03
- ÐÔ±ð: GG
- רҵ: Ó¦Óû¯Ñ§
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zy830226(½ð±Ò+2,VIP+0):¼ÌÐø
zy830226(½ð±Ò+2,VIP+0):¼ÌÐø
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ÏÂÃæµÄÊÇÎÒ¶ÔÄã·ÒëµÄ½øÐÐÁ˼¸µãССµÄÐ޸ģ¬Ï£ÍûÓÐÓá£ÒòΪûÓÐÔÎÄ£¬ËùÒÔÈç¹ûÓдíÎóµÄµØ·½£¬»¹Çë¶à¶à°üº¬¡£ The conclusion that TNF¦Áis a trigger of spontaneous pain, also be proved with minocycline preoperative in mSNA rats. Because the TNF¦Áexpression was suppressed in mSNA rats with minocycline preoperative. As we all known, minocycline is a kind of drug with strong anti-inflammatory . Minocycline can deeply suppress recruitment of macrophages, microglial activation [39], inflammatory cytokines releasing. Thus it can suppress TNF¦Áexpressing in the spinal dorsal horn of mSNA rats in our studies. And the SFL behavior was alleviated too. Our result is also consistent with Ik-Hyun Cho report that the SFL behavior is suppressed with minocycline pre-surgery in the inflammatory pain rats [14]. |
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