| 查看: 505 | 回复: 7 | ||
| 【奖励】 本帖被评价5次，作者xuzhj01增加金币 5 个 | ||
| 当前主题已经存档。 | ||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | ||
[资源]
（已搜-无）发一本书Structure-Based Ligand Design
|
||
|
药物设计版太冷清了，发帖聚聚人气。 我是做药物设计的新手，希望这个板块可以繁荣起来。 如有违反什么规定，请斑竹删除，谢谢！ Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry) By Klaus Gubernator, Hans-Joachim B%26ouml;hm, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman Publisher: Wiley-VCH Number Of Pages: 167 Publication Date: 1998-09-01 ISBN-10 / ASIN: 3527293434 ISBN-13 / EAN: 9783527293438 Binding: Hardcover Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery. http://www.filefactory.com/file/6e4c87/ http://rapidshare.com/files/107392025/3527293434.rar |
回复此楼» 猜你喜欢
重庆交大26年硕士生招生拟调剂通知已出！欢迎加入光子学微结构与器件课题组。
已经有0人回复
-
UJN物理学专业调剂
已经有12人回复
-
物理学I论文润色/翻译怎么收费?
已经有118人回复
-
北京纳米能源与系统研究所王中林院士/曹南颖研究员课题组招收2026硕士研究生1名
已经有0人回复
-
山西大同大学物理学硕士研究生招收调剂生
已经有0人回复
-
[调剂信息]211智能人工感知方向国家青年特聘专家课题组招收调剂研究生
已经有0人回复
-
［调剂信息］211智能人工感知方向国家青年特聘专家课题组招收调剂研究生
已经有0人回复
-
[调剂信息]211智能人工感知方向国家青年特聘专家课题组招收调剂研究生
已经有0人回复
-
一志愿物理所凝聚态物理352求调剂
已经有0人回复
-
0702一志愿吉大B区求调剂 本科期间发表一篇Sci
已经有1人回复
3楼2008-05-05 19:33:30
2楼2008-05-03 23:26:41
4楼2008-05-06 09:55:45
5楼2008-05-08 19:42:15
