| 查看: 460 | 回复: 7 | ||
| 【奖励】 本帖被评价5次，作者xuzhj01增加金币 5 个 | ||
| 当前主题已经存档。 | ||
[资源]
（已搜-无）发一本书Structure-Based Ligand Design
|
||
|
药物设计版太冷清了，发帖聚聚人气。 我是做药物设计的新手，希望这个板块可以繁荣起来。 如有违反什么规定，请斑竹删除，谢谢！ Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry) By Klaus Gubernator, Hans-Joachim B%26ouml;hm, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman Publisher: Wiley-VCH Number Of Pages: 167 Publication Date: 1998-09-01 ISBN-10 / ASIN: 3527293434 ISBN-13 / EAN: 9783527293438 Binding: Hardcover Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery. http://www.filefactory.com/file/6e4c87/ http://rapidshare.com/files/107392025/3527293434.rar |
回复此楼» 猜你喜欢
求取一些关于纳米材料和纳米技术相关的英文PPT。
已经有0人回复
-
【复旦大学】二维材料方向招收2026年博士研究生1名
已经有0人回复
-
物理学I论文润色/翻译怎么收费?
已经有78人回复
-
北京纳米能源与系统研究所 王中林院士/曹南颖研究员课题组2026级硕/博/博后招生
已经有10人回复
-
荷兰Utrecht University超快太赫兹光谱王海教授课题招收2026 CSC博士生
已经有22人回复
-
反铁磁体中的磁性切换：两种不同的机制已成功可视化
已经有0人回复
-
26申博推荐：南京航空航天大学国际前沿科学研究院光学方向招收博士生！
已经有0人回复
-
求标准粉末衍射卡号 ICDD 01-076-1802
已经有0人回复
-
新西兰Robinson研究所招收全奖PhD
已经有0人回复
2楼2008-05-03 23:26:41
3楼2008-05-05 19:33:30
4楼2008-05-06 09:55:45
5楼2008-05-08 19:42:15
6楼2008-05-09 21:48:12