| 查看: 517 | 回复: 7 | ||
| 【奖励】 本帖被评价5次，作者xuzhj01增加金币 5 个 | ||
| 当前主题已经存档。 | ||
[资源]
（已搜-无）发一本书Structure-Based Ligand Design
|
||
|
药物设计版太冷清了，发帖聚聚人气。 我是做药物设计的新手，希望这个板块可以繁荣起来。 如有违反什么规定，请斑竹删除，谢谢！ Structure-based Ligand Design (Methods and Principles in Medicinal Chemistry) By Klaus Gubernator, Hans-Joachim B%26ouml;hm, Raimund Mannhold, Hugo Kubinyi, Hendrik Timmerman Publisher: Wiley-VCH Number Of Pages: 167 Publication Date: 1998-09-01 ISBN-10 / ASIN: 3527293434 ISBN-13 / EAN: 9783527293438 Binding: Hardcover Most drugs bind to a clearly defined macromolecular target that is complementary in terms of structure and chemistry. This observation is the basic paradigm of structure-based ligand design. Although this method first emerged in the 1980s, it has already become a powerful tool for pharmaceutical research. Much has been learned, however, since the first attempts to discover drugs on the basis of available biochemical and structural data. Nowadays, structure-based ligand design is an established method for creating drugs with new structural features, for modifying binding activities and pharmacokinetic properties, and for elucidating binding modes and structure-activity relationships. This volume presents the underlying principles of the approach and highlights real-life applications such as the discovery of HIV-protease inhibitors. It shows that structure-based ligand design has many advantages over other more traditional approaches to designing new drugs, providing it is employed properly and with a thorough knowledge of the pitfalls to avoid. The straightforward presentation and extensive list of references to the original literature as well as numerous color figures illustrating structural relationships make this volume an indispensable tool for every scientist working in the area of drug discovery. http://www.filefactory.com/file/6e4c87/ http://rapidshare.com/files/107392025/3527293434.rar |
回复此楼» 猜你喜欢
26申博推荐：南京航空航天大学国际前沿院光学方向招收博士生！
已经有1人回复
-
如何从铁电相到顺电相。
已经有1人回复
-
物理学I论文润色/翻译怎么收费?
已经有132人回复
-
各位大佬，求一份最新Wien2k版本作为学习用途
已经有0人回复
-
南科大活性流体和软物质课题组诚招2027级博士、硕士研究生和博后
已经有38人回复
-
瑞典林雪平大学博士后招聘｜PEC Water Splitting 方向
已经有24人回复
-
PRB投稿，Acknowledgment sent to author状态十天了
已经有3人回复
-
PVA溶解
已经有1人回复
-
基金申请
已经有44人回复
2楼2008-05-03 23:26:41
3楼2008-05-05 19:33:30
4楼2008-05-06 09:55:45
5楼2008-05-08 19:42:15
6楼2008-05-09 21:48:12