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[求助]
求助一段话翻译 谢谢
Organs affected by doxycycline administration in both rats and Cynomolgus monkeys were the stomach and thyroid. In rats, both the glandular and non-glandular stomachs were affected. Effects in the rat non-glandular stomach included spongiosis at the limiting ridge, submucosal inflammation, hyperkeratosis and increased incidence of epithelial hyperplasia but these findings are not discussed further here as the non-glandular stomach does not have a counterpart in humans. From clinical experience, doxycycline is known to be irritant to the gastric and oesophageal mucosas. At 600 mg/kg/day in the 13 week rat study, focal erosion in the glandular stomach was of sufficient severity to cause or contribute to death in 2 animals but it was not observed at lower doses. Other changes in the glandular stomach included increased mucus producing cells/mucus production, observed in both rats and monkeys, and submucosal inflammation and eosinophilic chief cells, observed only in rats. In rats, other parts of the gastrointestinal tract (small and large intestines) were also affected, which may have been due to changes in intestinal flora. At doses ≥400 mg/kg/day (13 week study), diffuse mucosal hyperplasia was observed in both the duodenum and caecum and, additionally, villus hypertrophy was observed in the caecum. The NOEL for gastrointestinal lesions was 25 mg/kg/day in rats (ERAUC 2) and 30 mg/kg/day in monkeys (ERAUC 2.5 based on the 1 year study). |
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