| 查看: 819 | 回复: 0 | |||
[交流]
吉林大学 纳微构筑化学国际合作联合实验室
|
|
The Meguellati/Yang Group is a multidisciplinary and highly innovative group located at Jilin University in Changchun. We are looking for a highly motivated organic chemist. Jilin University is among the best university in China with very impressive facilities, among the best students. Meguellati group is member of NMAC International Joint Laboratory and has several collaborations with top-level scientists including Professors Jean-Marie Lehn, Ned Seeman, Frank McKeon, Reza Ghadiri and is willing to develop top-level research and innovations. We are willing to publish several top-level papers in Nature, Science, Cell and if you are interested in this truly experience, highly-motivated, dedicated, you want to work at the interface of organic chemistry, Biology. Please email Professor Kamel Meguellati: kameljilin@gmail.com Website：http://supramol.jlu.edu.cn/peopl ... 484&admin_id=29 国内PhD年薪12万起，国外PhD年薪16万起，欢迎联系我们申请博后岗位！ywyang@jlu.edu.cn 或 email Kamel Meguellati博士（kameljilin@gmail.com） Abstract: The aim of this research will consist in the design of pH sensitive rotaxane-based polymers that self-assemble into nanoparticles and sensible to the acidic extracellular pH of cancer cells for specific drug delivery to cancer cells. We will also design other kind of nanoparticles and vesicles in order to deliver specifically drugs to cancer cells. The aim of this research will also consist in the design of small molecules that can interact with biologically relevant DNA secondary structures such as the G-quadruplexes or triplexes or with G-actin monomer, hence interfering with cell replication and proliferation of cancer cells. Key-words: Chemical biology, Drug Design, Drug Delivery, Nanotechnology, Supramolecular Chemistry, Cancer , Dynamic Combinatorial Chemistry, Orthogonality, self-assembly, self-replicating, synthetic life, nanobots. 1. Main project (short term): Design of molecular nanomachines pH-sensitive for specific drug delivery to cancer cells. Design of rotaxane-based nanoparticles. Design of vesicles and nanoparticles with different levels i.e quantum dots with a core of Cd/Se and different shells of drugs coated by other shells of polyelectrolytes useful for specific drug delivery to cancer cells. 2. Long term: Design of templated-assisted synthetic G-quadruplexes that will be used as nuclease and useful for the development of the first G-quadruplex nucleome in combinaison of nucleic acid arrays and also for inducing cancer cells apoptosis. 3. Long term: Study of the different types of DNA polymorphisms via chemical reactions in order to understand the mechanism of transcription/replication: use of DNA as DNAzyme and nanoreactors. Perspectives: gene activation/deactivation without transcription factors. 4. Long term: Development of a new generation of autonomous artificial cells based on the concept of orthogonality with new supramolecular signalling pathways and chemical network……. |
回复此楼» 猜你喜欢
售SCI一区文章，我:8.O.551.O.5.4,科目全,可伽急
已经有3人回复
-
售SCI一区文章，我:8O5.5.1.O5.4,科目全,可伽急
已经有3人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有4人回复
-
售SCI一区T0P文章，我:8O.55.1.O.54,科目全,可伽急
已经有4人回复
-
怎么看青基中了没有啊
已经有6人回复
-
国社科又开始会评了，不知道这次命运如何
已经有11人回复
-
售SCI一区文章，我:8.O.55.1.O.54,科目齐全,可伽急
已经有3人回复
-
售SCI文章，我:8O.5.5.1O.54,科目全,可十急
已经有3人回复
-
有多少人是今天查系统知道结果的？
已经有19人回复
-
基金未中，这种答复是模板吗？
已经有7人回复
找到一些相关的精华帖子，希望有用哦~
中科院生物基材料重点实验室招收环境化学专业联合培养博、硕士研究生
已经有12人回复
- 吉林大学无机合成与制备化学国家重点实验室招聘博士后
已经有3人回复
- 中国科学院上海有机化学研究所生命有机国家重点实验室现招收联合培养研究生
已经有13人回复
点击这里搜索更多相关资源科研从小木虫开始，人人为我，我为人人
投票:
30