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【答案】应助回帖
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snicl: 金币+10, 翻译EPI+1, ★有帮助 2014-09-23 15:30:30
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After having discussed the correlation between the concentration of DPPIV in the serum and different morbid states of COPD, the concentration’s ability of providing evidences for diagnosing the disease and its accuracy are analyzed in this paper so as to select serum marker for COPD. Based on collected case data of both outpatients and hospitalized patients from pneumology department of central hospital in Baotou City from January to December, 2013, 42 cases diagnosed with acute exacerbation patients of COPD are marked as AECOPD group, and after having received corresponding treatment and clinical symptoms eased up, the same 42 patients are marketed as treated group of COPD, and 32 visiting patients who haven’t caught acute exacerbation symptom for over 3 months are marked as stable group of COPD, and finally, 29 middle-aged and elderly and healthy persons randomly selected from Physical Examination Center (PEC) of the hospital are marked as healthy control group. Then, measure the concentration of DPPIV with the enzyme-linked immunosorbent assay (ELISA) method, compare the concentration difference among persons from healthy control group, stable group, AECOPD group, and the concentration difference before and after the corresponding treatment as well. Observe the correlation between the concentration of DPPIV and the age, and evaluate the concentration’s ability of providing evidences for diagnosing the disease-COPD with ROC curve analytical approach. The results show that, compared with people from healthy control group, concentrations of DPPIV of patients from stable group, AECOPD group, treated group are much lower ( P<0.001), and after having received treatment, the concentration of the patients from AECOPD group have increased (P<0.001), and the concentration is unrelated to age, gender and smoking history (P>0.05). In addition, the area under the concentration-based ROC curve has reached 0.9 and the degree of specificity 0.931and the degree of sensitivity above 0.75. In a word, concentration of DPPIV of COPD patient is lower than healthy person, unrelated to age and gender, and thus can serve as a good serum marker matter and can provide rich evidence for diagnosing COPD. DPPIV in the serum serves as a protective matter for COPD. |
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