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dengxianqing木虫 (小有名气)
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[求助]
帮忙查一篇论文的检索号和他引情况
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| Xian-Qing Deng, Chun-Rui Xiao, Cheng-Xi Wei, Zhe-Shan Quan. Synthesis and Anticonvulsant Activity of 5-Substituted-[1,2,4]triazolo[4,3-a]quinazolines. CHINESE J ORG CHEM, 2011, 31(12):2082. |
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baiyuefei
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风雪
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【答案】应助回帖
★ ★ ★
感谢参与，应助指数 +1
dengxianqing: 金币+3, ★★★★★最佳答案 2014-09-20 12:41:15
oven1986: LS-EPI+1, 感谢应助！ 2014-09-21 00:37:11
感谢参与，应助指数 +1
dengxianqing: 金币+3, ★★★★★最佳答案 2014-09-20 12:41:15
oven1986: LS-EPI+1, 感谢应助！ 2014-09-21 00:37:11
2楼2014-09-20 11:59:32
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4643 (副教授)
- 贵宾: 46.97
- 金币: 659096
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- 帖子: 69636
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【答案】应助回帖
★ ★
dengxianqing: 金币+2 2014-09-20 12:41:40
dengxianqing: 金币+2 2014-09-20 12:41:40
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Synthesis and Anticonvulsant Activity of 5-Substituted-[1,2,4]triazolo[4,3-a]quinazolines 作者  eng, XQ (Deng Xianqing)[ 1 ] ; Xiao, CR (Xiao Chunrui)[ 1 ] ; Wei, CX (Wei Chengxi)[ 1 ] ; Quan, ZS (Quan Zheshan)[ 1 ] CHINESE JOURNAL OF ORGANIC CHEMISTRY 卷: 31 期: 12 页: 2082-2087 出版年: DEC 2011 查看期刊信息 摘要 A series of 5-substituted-[1,2,4]triazolo[4,3-a]quinazolines were synthesized. The anticonvulsant effects and neurotoxicity of the compounds were evaluated with maximal electroshock test and rotarod test with intraperitoneally injected in mice. The pharmacology results showed that 5-pentyloxy-[1,2,4]triazolo[4,3-a]quinazoline (2d) was the most potent with ED50 value of 19.7 mg/kg and protective index (PI=TD50/ED50) value of 6.2. To explain the possible mechanism of anticonvulsant activity, compound 2d was tested in several chemical induced seizures tests. The results revealed that compound 2d was effective against the seizures induced by pentylenetetrazole, isoniazid, 3-mercaptopropionic acid and thiosemicarbazide, which suggested that the anticonvulsant effects of this series compounds were acted via increasing gamma-aminobutyric acid (GABA) ergic neurotransmission and activating glutamate decarboxylase (GAD) or inhibiting a-oxoglutarate aminotransferase (GABA-T) in the brain. 关键词 作者关键词:triazoloquinazoline; synthesis; anticonvulsant; pentylenetetrazole; rotarod test KeyWords Plus:ANTIEPILEPTIC DRUGS; SEIZURES; EPILEPSY; GABA 作者信息 通讯作者地址: Deng, XQ (通讯作者) Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China. 地址: [ 1 ] Yanbian Univ, Coll Pharm, Yanji 133002, Peoples R China 电子邮件地址:zsquan@ybu.edu.cn 出版商 SCIENCE PRESS, 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Organic 文献信息 文献类型:Article 语种:Chinese 入藏号: WOS:000299064500013 ISSN: 0253-2786 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: 875VY Web of Science 核心合集中的 "引用的参考文献": 17 Web of Science 核心合集中的 "被引频次": 3 |
3楼2014-09-20 11:59:42
baiyuefei
版主 (文学泰斗)
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- LS-EPI: 1647
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4楼2014-09-20 11:59:55
baiyuefei
版主 (文学泰斗)
风雪
- LS-EPI: 1647
- 应助: 4643 (副教授)
- 贵宾: 46.97
- 金币: 659096
- 散金: 11616
- 红花: 995
- 沙发: 81
- 帖子: 69636
- 在线: 13543.3小时
- 虫号: 676696
- 注册: 2008-12-18
- 性别: GG
- 专业: 合成药物化学
- 管辖: 有机交流
【答案】应助回帖
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被引频次: 3 https://apps.webofknowledge.com/ ... FromNonInterProduct 1. Synthesis and In vitro Anticancer Activity of Novel Quinazoline Derivatives Containing Thiosemicarbazone Structure 作者: Liu Haibin; Lu Ping; Pan Ningning; 等. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 卷: 35 期: 5 页: 981-988 出版年: MAY 2014 出版商处的全文 查看摘要 被引频次: 0 (来自 Web of Science 的核心合集) 2. Regioselective Multi-component Synthesis of 7-Aryl-benzo[h][1,2,4]-triazolo[5,1-b]quinazoline-5,6-diones Catalyzed by n-Propylsulfonated gamma-Al2O3 作者: Li, Weilin; Tian, Shuanbao; Wu, Liqiang BULLETIN OF THE KOREAN CHEMICAL SOCIETY 卷: 34 期: 9 页: 2825-2828 出版年: SEP 20 2013 出版商处的全文 被引频次: 0 (来自 Web of Science 的核心合集) 3. Synthesis and Fungicidal Activity of 1,2,4-Triazole Derivatives Containing 2-Fluorophenyl Moiety 作者: Tong Jianying; Shi Yanxia; Liu Xinghai; 等. CHINESE JOURNAL OF ORGANIC CHEMISTRY 卷: 32 期: 12 页: 2373-2377 出版年: DEC 2012 出版商处的全文 查看摘要 |
5楼2014-09-20 12:14:27
