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dengxianqing: ½ð±Ò+5, ¡ï¡ï¡ïºÜÓаïÖú 2014-09-20 09:41:10
dengxianqing: ½ð±Ò+5, ¡ï¡ï¡ïºÜÓаïÖú 2014-09-20 09:41:10
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Synthesis and antibacterial evaluation of rhodanine-based 5-aryloxy pyrazoles against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA and QRSA) ×÷Õß:Song, MX (Song, Ming-Xia)[ 1,2 ] ; Zheng, CJ (Zheng, Chang-Ji)[ 1 ] ; Deng, XQ (Deng, Xian-Qing)[ 1 ] ; Sun, LP (Sun, Liang-Peng)[ 1 ] ; Wu, Y (Wu, Yan)[ 1 ] ; Hong, L (Hong, Lan)[ 3 ] ; Li, YJ (Li, Ying-Jing)[ 1 ] ; Liu, Y (Liu, Yi)[ 1 ] ; Wei, ZY (Wei, Zhi-Yu)[ 1 ] ; Jin, MJ (Jin, Ming-Jun)[ 1 ] ¸ü¶àÄÚÈÝ EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY ¾í: 60 Ò³: 376-385 DOI: 10.1016/j.ejmech.2012.12.007 ³ö°æÄê: FEB 2013 ²é¿´ÆÚ¿¯ÐÅÏ¢ ÕªÒª With an intention to synergize the anti-bacterial activity of 5-aryloxy pyrazole and rhodanine derivatives, eight series of hybrid compounds have been synthesized and evaluated for their antibacterial activity. The majority of the synthesized compounds showed good inhibitory activity against selected methicillin resistant and quinolone-resistant Staphylococcus aureus (MRSA, QRSA) with minimum inhibitory concentration (MIC) values in the range of 1-32 mu g/mL. The cytotoxicity test suggests that these compounds exhibited in vitro antibacterial activity at non-cytotoxic concentrations. These studies therefore suggest that rhodanine-based 5-aryloxy pyrazoles are interesting scaffolds for the development of novel Gram-positive antibacterial agents. (C) 2012 Elsevier Masson SAS. All rights reserved. ¹Ø¼ü´Ê ×÷Õ߹ؼü´Ê:Rhodanine; 5-Aryloxy pyrazole; Anti-bacterial; MRSA; QRSA KeyWords Plus ERIVATIVES; 4-THIAZOLIDINONE; AGENTS ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Piao, HR (ͨѶ×÷Õß) Yanbian Univ, Coll Pharm, Affiliated Minist Educ, Key Lab Nat Resources & Funct Mol Changbai Mt, 977 Gongyuan Rd, Yanji 133002, Jilin, Peoples R China. µØÖ·: [ 1 ] Yanbian Univ, Coll Pharm, Affiliated Minist Educ, Key Lab Nat Resources & Funct Mol Changbai Mt, Yanji 133002, Jilin, Peoples R China [ 2 ] Jinggangshan Univ, Coll Med, Jian 343100, Jiangxi, Peoples R China [ 3 ] Yanbian Univ, Coll Med, Yanji 133002, Jilin, Peoples R China µç×ÓÓʼþµØÖ·:piaohuri@yahoo.com.cn »ù½ð×ÊÖúÖÂл »ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ National Science Foundation of China 20962021 81260468 ²é¿´»ù½ð×ÊÖúÐÅÏ¢ ³ö°æÉÌ ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER, 23 RUE LINOIS, 75724 PARIS, FRANCE Àà±ð / ·ÖÀà Ñо¿·½Ïò harmacology & PharmacyWeb of Science Àà±ð:Chemistry, Medicinal ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Article ÓïÖÖ:English Èë²ØºÅ: WOS:000316242700038 ISSN: 0223-5234 ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ IDS ºÅ: 107TC Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 13 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 3 »¯ºÏÎï 1 ÖÁ 10 1. »¯ºÏÎïÏêϸÐÅÏ¢ 2. »¯ºÏÎïÏêϸÐÅÏ¢ 3. »¯ºÏÎïÏêϸÐÅÏ¢ 4. »¯ºÏÎïÏêϸÐÅÏ¢ 5. »¯ºÏÎïÏêϸÐÅÏ¢ 6. »¯ºÏÎïÏêϸÐÅÏ¢ 7. »¯ºÏÎïÏêϸÐÅÏ¢ 8. »¯ºÏÎïÏêϸÐÅÏ¢ 9. »¯ºÏÎïÏêϸÐÅÏ¢ 10. »¯ºÏÎïÏêϸÐÅÏ¢ ÒýÎÄÍøÂç 3 ±»ÒýƵ´Î 13 ÒýÓõIJο¼ÎÄÏ× ²é¿´ Related Records ²é¿´ÒýÖ¤¹ØÏµÍ¼ ´´½¨ÒýÎĸú×Ù (Êý¾ÝÀ´×Ô Web of ScienceTM ºËÐĺϼ¯) È«²¿±»ÒýƵ´Î¼ÆÊý 3 / ËùÓÐÊý¾Ý¿â 3 / Web of Science ºËÐĺϼ¯ 3 / BIOSIS Citation Index 0 / Öйú¿ÆÑ§ÒýÎÄÊý¾Ý¿â 0 / Data Citation Index 0 / SciELO Citation Index ×î½üµÄÒýÎÄ Ma, Long-Xu. Synthesis and positive inotropic evaluation of [1,2,4]triazolo [3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, APR 1 2014. ²é¿´È«²¿ ´Ë¼Ç¼À´×Ô: Web of ScienceTM ºËÐĺϼ¯ ½¨ÒéÐÞÕý Èç¹ûÏ£ÍûÌá¸ß´Ë¼Ç¼ÖÐÊý¾ÝµÄÖÊÁ¿£¬ÇëÌṩÐÞÕý½¨Òé¡£ |
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