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ÌâÄ¿£ºThe Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes

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Abstract
Dendrobium huoshanense is a valuable and versatile Chinese herbal medicine with the anecdotal claims of cancer prevention
and anti-inflammation. However, its immunological activities are limited to in vitro studies on a few cytokines and immune
cell functions. First, we investigated the effects of polysaccharides isolated from DH (DH-PS) on inducing a panel of
cytokines/chemokines in mice in vivo and human in vitro. We found that DH polysaccharides (DH-PS) induced TH1, TH2,
inflammatory cytokines and chemokines in mouse in vivo and human cells in vitro. Secondly, we demonstrated that DH-PS
expanded mouse splenocytes in vivo including CD4+ T cells, CD8+ T cells, B cells, NK cells, NKT cells, monocytes/
macrophages, granulocytes and regulatory T cells. Notably, DH-PS induced an anti-inflammatory molecule, IL-1ra, in mouse
and human immune cells, especially monocytes. The serum level of IL-1ra elicited by the injection of DH-PS was over 10
folds of IL-1b, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated
by IL-1b. The signaling pathways of DH-PS-induced IL-1ra production was shown to involve ERK/ELK, p38 MAPK, PI3K and
NFkB. Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide
extract isolated from another popular Chinese herbal medicine, Ganoderma lucidum. These results indicated that DH-PS
might have potential applications for ameliorating IL-1-induced pathogenic conditions.

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