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AnnF版主 (文坛精英)
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[求助]
【药理】求翻译一段英文摘要，金币双手奉上！谢谢~
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题目：The Multifaceted Effects of Polysaccharides Isolated from Dendrobium huoshanense on Immune Functions with the Induction of Interleukin-1 Receptor Antagonist (IL-1ra) in Monocytes 摘要： Abstract Dendrobium huoshanense is a valuable and versatile Chinese herbal medicine with the anecdotal claims of cancer prevention and anti-inflammation. However, its immunological activities are limited to in vitro studies on a few cytokines and immune cell functions. First, we investigated the effects of polysaccharides isolated from DH (DH-PS) on inducing a panel of cytokines/chemokines in mice in vivo and human in vitro. We found that DH polysaccharides (DH-PS) induced TH1, TH2, inflammatory cytokines and chemokines in mouse in vivo and human cells in vitro. Secondly, we demonstrated that DH-PS expanded mouse splenocytes in vivo including CD4+ T cells, CD8+ T cells, B cells, NK cells, NKT cells, monocytes/ macrophages, granulocytes and regulatory T cells. Notably, DH-PS induced an anti-inflammatory molecule, IL-1ra, in mouse and human immune cells, especially monocytes. The serum level of IL-1ra elicited by the injection of DH-PS was over 10 folds of IL-1b, suggesting that DH-PS-induced anti-inflammatory activities might over-ride the inflammatory ones mediated by IL-1b. The signaling pathways of DH-PS-induced IL-1ra production was shown to involve ERK/ELK, p38 MAPK, PI3K and NFkB. Finally, we observed that IL-1ra level induced by DH-PS was significantly higher than that by F3, a polysaccharide extract isolated from another popular Chinese herbal medicine, Ganoderma lucidum. These results indicated that DH-PS might have potential applications for ameliorating IL-1-induced pathogenic conditions. ..  1.jpg  2.jpg |
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【答案】应助回帖
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RXMCDM: 金币+1, 多谢应助！ 2014-09-14 12:08:57
AnnF: 金币+25, 翻译EPI+1, ★★★★★最佳答案, 谢谢~有劳了！ 2014-09-14 13:15:28
RXMCDM: 金币+1, 多谢应助！ 2014-09-14 12:08:57
AnnF: 金币+25, 翻译EPI+1, ★★★★★最佳答案, 谢谢~有劳了！ 2014-09-14 13:15:28
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从霍山石斛分离的多糖通过在单核细胞诱导白细胞介素-1受体拮抗剂（IL-1ra）进而从多方面影响免疫功能 摘要: 霍山石斛是一种有价值的和多种作用的中国草药，据称有防癌和抗炎作用。但是其免疫学活性仅限于对几种细胞因子和免疫细胞功能的体外研究。首先，我们研究了从霍山石斛分离的多糖（DH-PS）在小鼠体内以及在人的体外对一组细胞因子/化学趋化因子的诱导作用。细胞因子/小鼠体内和人的体外趋化因子。我们发现，DH-PS在小鼠体内和人类体外培养细胞诱导诱导TH1，TH2，炎症细胞因子和化学趋化因子。其次，我们证明了DH-PS可以在体内扩大小鼠脾细胞，包括CD4+ T细胞，CD8+ T细胞，B细胞，NK细胞，NKT细胞，单核细胞/巨噬细胞，粒细胞和调节性T细胞。值得注意的是，DH-PS在小鼠和人类免疫细胞，特别是单核细胞中诱导一种抗炎分子，即IL-1ra（白细胞介素-1受体拮抗剂）。向小鼠体内注射DH-PS引起血清IL-1ra水平的升高超过IL-1β 10倍，提示DH-PS诱导的抗炎活性可能超过由IL-1β介导的炎性反应。已经证明，DH-PS诱导产生IL-1ra的信号转导途径包括ERK/ELK，p38 MAPK，PI3K和NFkB。最后，我们观察到DH-PS诱导的IL-1ra水平明显高于F3诱导的水平，F3也是一种多糖，由另一种流行的中国草药灵芝中分离获得。这些结果表明，DH-PS可能对于由IL-1诱导的致病状况的改善具有潜在的应用价值。 |
2楼2014-09-14 11:08:05
