至尊木虫 (知名作家)
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liyan20220: 金币+25, 翻译EPI+1, ★★★★★最佳答案 2014-09-12 09:19:04
你的中文摘要最后两句话“并探索抗结核分枝杆菌多肽PK34的抗结核分枝杆菌作用机理，为阐明其抗结核分枝杆菌的作用机理提供重要的理论依据”是重复的（说了同一件事）。我在翻译时将最后一句变成了为其抗结核治疗作用提供重要理论基础，不知是否合适。
Tuberculosis (TB) is a respiratory infectious disease caused by Mycobacterium tuberculosis, a major pathogenic bacterial species in the family Mycobacteriaceae. With the large-scale application of a variety of effective antibiotics (to control TB), multidrug-resistant Mycobacterium tuberculosis strains emerged, which cannot be treated effectively with the traditional antibiotics. Therefore, it is the imminent to develop new anti-TB drugs. As a virus of eubacteria, a bacteriophage can infect and replicate within Mycobacterium tuberculosis. Recently, much attention has been paid to bacteriophage as an alternative to traditional antibiotic drugs. Polypeptide PK34, derived from Mycobacterium tuberculosis phage, is capable of getting rid of Mycobacterium tuberculosis from body. However, the underlying mechanisms of its anti-Mycobacterium tuberculosis effect has not been reported.
In this project, polypeptide PK34 of Mycobacterium tuberculosis will be obtained by utilizing of genetic engineering methods and the dynamic interaction between PK34 and TDM, as well as the solution structure of PK34 in the presence of TDM will be investigated with MRI as the main research tool, in combination with other methods, such as circular dichroism. The mechanisms of the anti-Mycobacterium tuberculosis effect of polypeptide PK34 will be explored in order to provide important theoretical basis for its therapeutic action. |
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