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liyan20220木虫 (著名写手)
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[求助]
求翻译一段为英文
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| 结核病是由人类重大病原菌结核杆菌引发的呼吸道传染病，随着多种有效控制结核病的抗生素的大量应用，多重耐药结核杆菌菌株大量出现，而传统抗生素无法达到治疗效果，因此，开发新型抗结核杆菌药物迫在眉睫。噬菌体作为一种真细菌的病毒，可以有效地与宿主细菌作用，作为替代传统抗生素的药物受到广泛的关注。多肽PK34来源于结核分枝杆菌噬菌体，具有清除体内结核分枝杆菌的能力，但是，目前其抗结核分枝杆菌的作用机制研究还未有报道，本项目拟利用基因工程法获得抗结核分枝杆菌多肽PK34，并利用核磁共振为主要研究手段，结合圆二色谱等其他手段，研究抗结核分枝杆菌多肽PK34与TDM相互作用的动态过程及其在TDM存在情况下的溶液结构，并探索抗结核分枝杆菌多肽PK34的抗结核分枝杆菌作用机理，为阐明其抗结核分枝杆菌的作用机理提供重要的理论依据。 |
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【答案】应助回帖
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liyan20220: 金币+25, 翻译EPI+1, ★★★★★最佳答案 2014-09-12 09:19:04
liyan20220: 金币+25, 翻译EPI+1, ★★★★★最佳答案 2014-09-12 09:19:04
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你的中文摘要最后两句话“并探索抗结核分枝杆菌多肽PK34的抗结核分枝杆菌作用机理，为阐明其抗结核分枝杆菌的作用机理提供重要的理论依据”是重复的（说了同一件事）。我在翻译时将最后一句变成了为其抗结核治疗作用提供重要理论基础，不知是否合适。 Tuberculosis (TB) is a respiratory infectious disease caused by Mycobacterium tuberculosis, a major pathogenic bacterial species in the family Mycobacteriaceae. With the large-scale application of a variety of effective antibiotics (to control TB), multidrug-resistant Mycobacterium tuberculosis strains emerged, which cannot be treated effectively with the traditional antibiotics. Therefore, it is the imminent to develop new anti-TB drugs. As a virus of eubacteria, a bacteriophage can infect and replicate within Mycobacterium tuberculosis. Recently, much attention has been paid to bacteriophage as an alternative to traditional antibiotic drugs. Polypeptide PK34, derived from Mycobacterium tuberculosis phage, is capable of getting rid of Mycobacterium tuberculosis from body. However, the underlying mechanisms of its anti-Mycobacterium tuberculosis effect has not been reported. In this project, polypeptide PK34 of Mycobacterium tuberculosis will be obtained by utilizing of genetic engineering methods and the dynamic interaction between PK34 and TDM, as well as the solution structure of PK34 in the presence of TDM will be investigated with MRI as the main research tool, in combination with other methods, such as circular dichroism. The mechanisms of the anti-Mycobacterium tuberculosis effect of polypeptide PK34 will be explored in order to provide important theoretical basis for its therapeutic action. |
2楼2014-09-12 07:42:29