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ÇóÄÄλÅóÓѰïæÓÃISI web of science¼ìË÷Ò»ÏÂÕâÆªÂÛÎÄThe Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring £¨BioMed Research International 2014,Volume 2014, Article ID 419805£©ÊÇ·ñ±»SCIÊÕ¼£¿Ð»Ð»¡£ |
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2Â¥2014-08-28 16:05:14
baiyuefei
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- LS-EPI: 1647
- Ó¦Öú: 4642 (¸±½ÌÊÚ)
- ¹ó±ö: 46.969
- ½ð±Ò: 658104
- É¢½ð: 11616
- ºì»¨: 995
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lxingwan: ½ð±Ò+10, ¡ï¡ï¡ïºÜÓаïÖú 2014-08-28 19:41:32
lxingwan: ½ð±Ò+10, ¡ï¡ï¡ïºÜÓаïÖú 2014-08-28 19:41:32
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The Influence of Hypoxia during Different Pregnancy Stages on Cardiac Collagen Accumulation in the Adult Offspring ×÷Õß:Wang, LX (Wang, Lingxing)[ 1 ] ; Li, MM (Li, Meimei)[ 2 ] ; Huang, ZY (Huang, Ziyang)[ 2 ] ; Wang, ZH (Wang, Zhenhua)[ 2 ] BIOMED RESEARCH INTERNATIONAL ÎÄÏ׺Å: 419805 DOI: 10.1155/2014/419805 ³ö°æÄê: 2014 ²é¿´ÆÚ¿¯ÐÅÏ¢ ÕªÒª We evaluated whether the timing of maternal hypoxia during pregnancy influenced cardiac extracellular matrix accumulation in the adult offspring. Rats in different periods of pregnancy were assigned to maternal hypoxia or control groups. Maternal hypoxia from day 3 to 21 of pregnancy or day 9 to 21 of pregnancy increased collagen I and collagen III expression in the left ventricle of adult offspring (both P < 0.05). Maternal hypoxia from day 15 to 21 of pregnancy had no effect on adult collagen levels. Our results indicate that maternal hypoxia at critical windows of cardiovascular development can induce pathological cardiac remodeling in the adult rat offspring. ¹Ø¼ü´Ê KeyWords Plus:FEMALE RATS; FIBROSIS; DISEASE; GROWTH; HYPERTENSION; RESTRICTION; LEADS; UNDERNUTRITION; HYPERTROPHY; MODEL ×÷ÕßÐÅÏ¢ ͨѶ×÷ÕßµØÖ·: Huang, ZY (ͨѶ×÷Õß) Fujian Med Univ, Dept Cardiol, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R China. µØÖ·: [ 1 ] Fujian Med Univ, Dept Neurol, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R China [ 2 ] Fujian Med Univ, Dept Cardiol, Affiliated Hosp 2, Quanzhou 362000, Fujian, Peoples R China µç×ÓÓʼþµØÖ·:ziyanghuang502@gmail.com »ù½ð×ÊÖúÖÂл »ù½ð×ÊÖú»ú¹¹ ÊÚȨºÅ Fujian Medical University Significant Research Project 09ZD015 Quanzhou Technology Projects, China 2012Z35 ²é¿´»ù½ð×ÊÖúÐÅÏ¢ ³ö°æÉÌ HINDAWI PUBLISHING CORPORATION, 410 PARK AVENUE, 15TH FLOOR, #287 PMB, NEW YORK, NY 10022 USA ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Article ÓïÖÖ:English Èë²ØºÅ: WOS:000337818100001 ISSN: 2314-6133 µç×Ó ISSN: 2314-6141 ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ IDS ºÅ: AJ6PM Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 21 Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0 |
3Â¥2014-08-28 16:05:26
lxingwan
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4Â¥2014-08-28 19:35:40
sunshan4379
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5Â¥2014-08-28 19:37:42
lxingwan
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6Â¥2014-08-28 19:41:57
lxingwan
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7Â¥2014-08-28 19:42:36













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