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H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells. Mol Biol Rep. 2012 Apr;39(4):4655-61

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H. pylori related proinflammatory cytokines contribute to the induction of miR-146a in human gastric epithelial cells
×÷Õß:Li, N (Li, Na)[ 1 ] ; Xu, X (Xu, Xiang)[ 2 ] ; Xiao, B (Xiao, Bin)[ 1 ] ; Zhu, ED (Zhu, En-Dong)[ 1 ] ; Li, BS (Li, Bo-sheng)[ 1 ] ; Liu, Z (Liu, Zhen)[ 1 ] ; Tang, B (Tang, Bin)[ 1 ] ; Zou, QM (Zou, Quan-Ming)[ 1 ] ; Liang, HP (Liang, Hua-Ping)[ 2 ] ; Mao, XH (Mao, Xu-Hu)[ 1 ]
MOLECULAR BIOLOGY REPORTS
¾í: 39  ÆÚ: 4  Ò³: 4655-4661
DOI: 10.1007/s11033-011-1257-5
³ö°æÄê: APR 2012
²é¿´ÆÚ¿¯ÐÅÏ¢
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MicroRNAs have been implicated as a central regulator of the immune system. We have previously reported that Helicobacter pylori (H. pylori) was able to increase the expression of miR-146a, and miR-146a may negatively regulate H. pylori-induced inflammation, but the exact mechanism of how H. pylori contribute the induction of miR-146a is not clear. Here, we attempted to assess the role of H. pylori related proinflammatory cytokines including interleukin (IL)-8, tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1 beta, and cytotoxin-associated gene A (CagA) virulence factor on the induction of miR-146a. We found that IL-8, TNF-alpha, and IL-1 beta could contribute to the induction of miR-146a in gastric epithelial cell HGC-27 in NF-kappa B-dependent manner, while the induction of miR-146a upon H. pylori stimulation was independent of above proinflammatory cytokines. Furthermore, overexpression of miR-146a reduced H. pylori-induced IL-8, TNF-alpha, and IL-1 beta. However, CagA had no effect on the miR-146a induction. Taken together, our study suggest that proinflammatory cytokines IL-8, TNF-alpha, and IL-1 beta could contribute to the induction of miR-146a during H. pylori infection, while CagA is not necessarily required for miR-146a induction. miR-146a may function as novel negative regulators to modulate the inflammation.
¹Ø¼ü´Ê
×÷Õ߹ؼü´Ê:miR-146a; H. pylori; Proinflammatory cytokines; CagA
KeyWords Plus:NORMAL IMMUNE FUNCTION; HELICOBACTER-PYLORI; INFLAMMATORY RESPONSE; RHEUMATOID-ARTHRITIS; T-CELLS; MICRORNAS; ACTIVATION; EXPRESSION; PHOSPHORYLATION; MECHANISM
×÷ÕßÐÅÏ¢
ͨѶ×÷ÕßµØÖ·: Xiao, B (ͨѶ×÷Õß)
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        Third Mil Med Univ, Dept Clin Microbiol & Immunol, Coll Med Lab Sci, Chongqing 400038, Peoples R China.
µØÖ·:
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 1 ] Third Mil Med Univ, Dept Clin Microbiol & Immunol, Coll Med Lab Sci, Chongqing 400038, Peoples R China
ÏÔʾÔöÇ¿×éÖ¯ÐÅÏ¢µÄÃû³Æ        [ 2 ] Third Mil Med Univ, State Key Lab Trauma Burns & Combined Injury, Dept 1, Inst Surg Res,Daping Hosp, Chongqing 400042, Peoples R China
µç×ÓÓʼþµØÖ·:binxiaotmmu@163.com; huaping_liang@yahoo.com.cn; xhmaotmmu@yeah.net
»ù½ð×ÊÖúÖÂл
»ù½ð×ÊÖú»ú¹¹        ÊÚȨºÅ
Scientific Innovation Research Foundation of Third Military Medical University        
2009XQN20
Chinese National Natural Science Foundation        
30770113
State Key Laboratory of Trauma, Burns, and Combined Injury        
SKF201012
²é¿´»ù½ð×ÊÖúÐÅÏ¢   
³ö°æÉÌ
SPRINGER, VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
Àà±ð / ·ÖÀà
Ñо¿·½Ïò:Biochemistry & Molecular Biology
Web of Science Àà±ð:Biochemistry & Molecular Biology
ÎÄÏ×ÐÅÏ¢
ÎÄÏ×ÀàÐÍ:Article
ÓïÖÖ:English
Èë²ØºÅ: WOS:000301108500147
ISSN: 0301-4851
ÆÚ¿¯ÐÅÏ¢
Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports®
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IDS ºÅ: 903HZ
Web of Science ºËÐĺϼ¯ÖÐµÄ "ÒýÓõIJο¼ÎÄÏ×": 25
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 7
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