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[求助]
求linifanib最新临床情况 已有1人参与
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求linifanib最新临床情况，最好包括临床类型及几期 还有这种药物的发展前景 |
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【答案】应助回帖
感谢参与，应助指数 +1
| AbbVie is developing linifanib, an orally active multi-targeted receptor tyrosine kinase inhibitor, for the treatment of cancer, including non-small cell lung cancer, breast cancer, colorectal cancer, renal cancer and hepatocellular carcinoma. Linifanib was being developed in collaboration with Genentech; however, development later reverted to Abbott. Linifanib acts as both a vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor tyrosine kinase inhibitor. It has been shown to stop disease progression by limiting tumour blood-flow. Linifanib is hydrophobic, but is oxidised in the body to A 849529, a hydrophilic metabolite that includes both carboxyl and amino groups. Linifanib is in phase II development for breast, renal, colorectal and non-small cell lung cancer. The compound was being investigated in a phase III trial for hepatocellular carcinoma, but the trial has been terminated. |
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2014-08-20 14:47:24, 87.78 K
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