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标题: Selective Substitution of 31/42-OH in Rapamycin Guided by an in Situ IR Technique.
作者: Cao, Shuang; Zhou, Xinbo; Yang, Yuanshuai; Zhong, Wu; Sun, Tiemin
来源出版物: Molecules (Basel, Switzerland)
卷: 19
期: 6
页: 7770-84
DOI: 10.3390/molecules19067770
出版年: 2014 Jun 10
摘要: An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH of rapamycin were chemically modified by a series of quaternary ammonium salts to generate 11 compounds. The solubility of all these compounds was remarkably improved (25,000 times higher than that of rapamycin) and their structures were confirmed by MS, IR, 1D and 2D NMR techniques.
PubMed ID: 24918544
文献类型: Journal Article
语种: English
地址: Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China. caoshuangknight@163.com.
分主题子库: Index Medicus
ISSN: 1420-3049
NLM 唯一 ID: 100964009
国家/地区: Switzerland
状态: In-Data-Review
创建日期: 12 Jun 2014   
电子出版: 10 Jun 2014
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2楼2014-07-30 23:40:33
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babyqiqi: 金币+10, ★★★★★最佳答案 2014-08-01 07:52:30
oven1986: 检索EPI+1, 感谢应助！ 2014-08-01 10:17:59
第 1 条，共 1 条
作者: Cao, Shuang; Zhou, Xinbo; Yang, Yuanshuai; Zhong, Wu; Sun, Tiemin
标题: Selective Substitution of 31/42-OH in Rapamycin Guided by an in Situ IR Technique.
来源出版物: Molecules (Basel, Switzerland)
卷: 19
期: 6
页: 7770-84
DOI: 10.3390/molecules19067770
出版年: 2014 Jun 10
摘要: An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH of rapamycin were chemically modified by a series of quaternary ammonium salts to generate 11 compounds. The solubility of all these compounds was remarkably improved (25,000 times higher than that of rapamycin) and their structures were confirmed by MS, IR, 1D and 2D NMR techniques.
Web of Science 核心合集中的 "被引频次": 0
在 BIOSIS Citation Index 中的被引频次: 0
在中国科学引文数据库中的被引频次: 0
SciELO Citation Index 中的 "被引频次": 0
被引频次合计: 0
ISSN: 1420-3049
入藏号: MEDLINE:24918544
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竹杖芒鞋轻胜马，一蓑烟雨任平生。
3楼2014-07-30 23:42:46
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