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±êÌâ: Selective Substitution of 31/42-OH in Rapamycin Guided by an in Situ IR Technique.
×÷Õß: Cao, Shuang; Zhou, Xinbo; Yang, Yuanshuai; Zhong, Wu; Sun, Tiemin
À´Ô´³ö°æÎï: Molecules (Basel, Switzerland)
¾í: 19
ÆÚ: 6
Ò³: 7770-84
DOI: 10.3390/molecules19067770
³ö°æÄê: 2014 Jun 10
ÕªÒª: An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH of rapamycin were chemically modified by a series of quaternary ammonium salts to generate 11 compounds. The solubility of all these compounds was remarkably improved (25,000 times higher than that of rapamycin) and their structures were confirmed by MS, IR, 1D and 2D NMR techniques.
PubMed ID: 24918544
ÎÄÏ×ÀàÐÍ: Journal Article
ÓïÖÖ: English
µØÖ·: Key Laboratory of Structure-Based Drug Design and Discovery, Shenyang Pharmaceutical University, Ministry of Education, Shenyang 110016, China. caoshuangknight@163.com.
·ÖÖ÷Ìâ×Ó¿â: Index Medicus
ISSN: 1420-3049
NLM Ψһ ID: 100964009
¹ú¼Ò/µØÇø: Switzerland
״̬: In-Data-Review
´´½¨ÈÕÆÚ: 12 Jun 2014   
µç×Ó³ö°æ: 10 Jun 2014
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babyqiqi: ½ð±Ò+10, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2014-08-01 07:52:30
oven1986: ¼ìË÷EPI+1, ¸ÐлӦÖú£¡ 2014-08-01 10:17:59
µÚ 1 Ìõ£¬¹² 1 Ìõ
×÷Õß: Cao, Shuang; Zhou, Xinbo; Yang, Yuanshuai; Zhong, Wu; Sun, Tiemin
±êÌâ: Selective Substitution of 31/42-OH in Rapamycin Guided by an in Situ IR Technique.
À´Ô´³ö°æÎï: Molecules (Basel, Switzerland)
¾í: 19
ÆÚ: 6
Ò³: 7770-84
DOI: 10.3390/molecules19067770
³ö°æÄê: 2014 Jun 10
ÕªÒª: An in situ IR technique was applied in the selective synthesis of the key intermediate for rapamycin derivatives, which made the reaction endpoint easily defined. This technology solved a bothersome problem in the preparation of rapamycin derivatives, and based on this technique, the 31-OH and 42-OH of rapamycin were chemically modified by a series of quaternary ammonium salts to generate 11 compounds. The solubility of all these compounds was remarkably improved (25,000 times higher than that of rapamycin) and their structures were confirmed by MS, IR, 1D and 2D NMR techniques.
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
ÔÚ BIOSIS Citation Index Öеı»ÒýƵ´Î: 0
ÔÚÖйú¿ÆÑ§ÒýÎÄÊý¾Ý¿âÖеı»ÒýƵ´Î: 0
SciELO Citation Index ÖÐµÄ "±»ÒýƵ´Î": 0
±»ÒýƵ´ÎºÏ¼Æ: 0
ISSN: 1420-3049
Èë²ØºÅ: MEDLINE:24918544
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