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【答案】应助回帖
★ ★ ★ ★ ★ ★ ★ ★ ★ ★
感谢参与，应助指数 +1
babyqiqi: 金币+10, ★★★★★最佳答案 2014-08-01 07:53:04
oven1986: 检索EPI+1, 感谢应助！ 2014-08-01 10:18:29
作者: Cao, S (Cao, Shuang); Zhou, XB (Zhou, Xin-Bo); Zhang, H (Zhang, Heng); Li, S (Li, Song); Zhong, W (Zhong, Wu)
标题: Novel cross-link breaker based on zwitterion structure: Synthesis, structure and druggability studies
来源出版物: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
卷: 68
页: 89-95
DOI: 10.1016/j.ejmech.2013.07.033
出版年: OCT 2013
摘要: It has been universally acknowledged that the increase in cardiac and vascular stiffness is due to the formation of advanced glycosylation end-products (AGEs). Research on the stable form of 3-(carboxymethyl)-4-methylthiazol bromide sodium salt (C6H7BrNNaO2S) showed that it had a notable effect on breaking the AGEs. Two compounds with novel structures, zwitterionic 3-(carboxymethyl)-4-methylthiazol (C6H7O2NS) and a dipolymer (C12H15O4N2S2Br) complex, were obtained. When compared with the forms of sodium salt and dipolymer, zwitterion had an obvious advantage in stability, solubility, synthesis and pH, which made the zwitterion a promising drug. The structure of sodium salt, dipolymer and zwitterion was comparatively analyzed by such methods as single crystal X-ray diffraction, ESI-MS, H-1 NMR, FT-IR and in situ IR. (C) 2013 The Authors. Published by Elsevier Masson SAS. All rights reserved.
Web of Science 核心合集中的 "被引频次": 0
在 BIOSIS Citation Index 中的被引频次: 0
在中国科学引文数据库中的被引频次: 0
SciELO Citation Index 中的 "被引频次": 0
被引频次合计: 0
ISSN: 0223-5234; 1768-3254
入藏号: WOS:000326902300010 |
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