²é¿´: 606  |  »Ø¸´: 1
±¾Ìû²úÉú 1 ¸ö LS-EPI £¬µã»÷ÕâÀï½øÐв鿴

babyqiqi

½û³æ (ÕýʽдÊÖ)

±¾ÌûÄÚÈݱ»ÆÁ±Î

ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû

gruyclewee

ÈÙÓþ°æÖ÷ (ÎÄ̳¾«Ó¢)

ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷ÓÅÐã°æÖ÷

¡¾´ð°¸¡¿Ó¦Öú»ØÌû

¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï ¡ï
¸Ðл²ÎÓ룬ӦÖúÖ¸Êý +1
babyqiqi: ½ð±Ò+10, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸ 2014-08-01 07:53:04
oven1986: ¼ìË÷EPI+1, ¸ÐлӦÖú£¡ 2014-08-01 10:18:29
×÷Õß: Cao, S (Cao, Shuang); Zhou, XB (Zhou, Xin-Bo); Zhang, H (Zhang, Heng); Li, S (Li, Song); Zhong, W (Zhong, Wu)
±êÌâ: Novel cross-link breaker based on zwitterion structure: Synthesis, structure and druggability studies
À´Ô´³ö°æÎï: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
¾í: 68
Ò³: 89-95
DOI: 10.1016/j.ejmech.2013.07.033
³ö°æÄê: OCT 2013
ÕªÒª: It has been universally acknowledged that the increase in cardiac and vascular stiffness is due to the formation of advanced glycosylation end-products (AGEs). Research on the stable form of 3-(carboxymethyl)-4-methylthiazol bromide sodium salt (C6H7BrNNaO2S) showed that it had a notable effect on breaking the AGEs. Two compounds with novel structures, zwitterionic 3-(carboxymethyl)-4-methylthiazol (C6H7O2NS) and a dipolymer (C12H15O4N2S2Br) complex, were obtained. When compared with the forms of sodium salt and dipolymer, zwitterion had an obvious advantage in stability, solubility, synthesis and pH, which made the zwitterion a promising drug. The structure of sodium salt, dipolymer and zwitterion was comparatively analyzed by such methods as single crystal X-ray diffraction, ESI-MS, H-1 NMR, FT-IR and in situ IR. (C) 2013 The Authors. Published by Elsevier Masson SAS. All rights reserved.
Web of Science ºËÐĺϼ¯ÖÐµÄ "±»ÒýƵ´Î": 0
ÔÚ BIOSIS Citation Index Öеı»ÒýƵ´Î: 0
ÔÚÖйú¿ÆÑ§ÒýÎÄÊý¾Ý¿âÖеı»ÒýƵ´Î: 0
SciELO Citation Index ÖÐµÄ "±»ÒýƵ´Î": 0
±»ÒýƵ´ÎºÏ¼Æ: 0
ISSN: 0223-5234; 1768-3254
Èë²ØºÅ: WOS:000326902300010
ÖñÕÈâЬÇáʤÂí£¬Ò»ËòÑÌÓêÈÎÆ½Éú¡£
2Â¥2014-07-30 23:41:50
ÒÑÔÄ   ¹Ø×¢TA ¸øTA·¢ÏûÏ¢ ËÍTAºì»¨ TAµÄ»ØÌû
Ïà¹Ø°æ¿éÌø×ª ÎÒÒª¶©ÔÄÂ¥Ö÷ babyqiqi µÄÖ÷Ìâ¸üÐÂ
×î¾ßÈËÆøÈÈÌûÍÆ¼ö [²é¿´È«²¿] ×÷Õß »Ø/¿´ ×îºó·¢±í
[˶²©¼ÒÔ°] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 bjm2e4yior 2026-07-18 3/150 2026-07-19 16:43 by 0u3sh5hhfi
[ÂÛÎÄͶ¸å] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 ufgqpyvpi6 2026-07-18 6/300 2026-07-19 16:23 by 0u3sh5hhfi
[¿¼²©] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 ufgqpyvpi6 2026-07-18 4/200 2026-07-19 16:10 by 0u3sh5hhfi
[˶²©¼ÒÔ°] ÊÛT0PÒ»ÇøSCIÎÄÕ£¬ÎÒ:8O5.51.O.54,¿ÆÄ¿ÆëÈ«,¿É£«¼± +3 ufgqpyvpi6 2026-07-18 4/200 2026-07-19 15:54 by 0u3sh5hhfi
[»ù½ðÉêÇë] ¹úÉç¿ÆÍ¨Ñ¶ÆÀÉó +5 DZˮ¹Ú¾ü123 2026-07-18 6/300 2026-07-19 12:28 by lfy8008
[»ù½ðÉêÇë] ÃæÉϵÄË®ºÜÉî +16 ²¼²¼ºÍÒ»¶þ 2026-07-18 21/1050 2026-07-19 10:07 by Vivilian
[»ù½ðÉêÇë] Сľ³æÃ»ÂäÁË£¬³ýÁËÆíµ»Ìû×Ó£¬¼¸ºõ¿´²»µ½ÓмÛÖµµÄÌû×Ó +14 botar 2026-07-14 15/750 2026-07-19 00:15 by beefly
[»ù½ðÉêÇë] 5¸ö%2F£¬·Ç¹Ì¶¨¶Î22¸ö×Öĸ +8 jaasxulu 2026-07-15 9/450 2026-07-18 17:40 by dxcgbm
[»ù½ðÉêÇë] ÉúÃü¿ÚC13ÃæÉÏ»áÆÀʱ¼ä +7 luckinging 2026-07-14 11/550 2026-07-17 20:43 by ³æ²·1988
[»ù½ðÉêÇë] ÉúÃü¿ÚÃæÉÏ»áÆÀ½áÊøÁËÂð´ó¼ÒÓÐÖªµÀ½á¹ûÂð£¿ÏÖÔÚ»¹Ã»Óнá¹ûÕý³£²»£¿ +6 ±ÌË®00 2026-07-16 9/450 2026-07-17 15:21 by jaasxulu
[ÂÛÎÄͶ¸å] ͶӢÎÄÆÚ¿¯ÈçºÎ²éÖØ 10+5 ²»ÖªµÀȡʲôÃû× 2026-07-15 6/300 2026-07-17 09:07 by bobvan
[Óлú½»Á÷] ²®°·Éϼ׻ùÇóÖú 100+4 002tmumu 2026-07-14 7/350 2026-07-16 19:47 by 002tmumu
[ÂÛÎÄͶ¸å] ¿ç³ö°æÉçÉÌͶ¸å 20+5 ÄߺÃ520 2026-07-13 5/250 2026-07-16 17:24 by ÎÞÊÓ¾üÍÅ
[»ù½ðÉêÇë] ÉúÉúÃüѧ²¿»áÆÀ +4 wuke100666 2026-07-15 4/200 2026-07-16 00:12 by À²À²Ð¡ÄÝ×Ó
[»ù½ðÉêÇë] H¿Ú£¬ÃæÉÏ£¬Ê±¼ä´Á7ÔÂ7ÈÕ¡£ +3 plumage5 2026-07-15 3/150 2026-07-15 21:06 by 6543yes
[»ù½ðÉêÇë] »áÆÀ +5 ÎÞÃûÕßµÇɽ 2026-07-15 5/250 2026-07-15 18:15 by ¸Ü¾ÍÊÇÄã¶Ô
[»ù½ðÉêÇë] E¿ÚÇàC»áÆÀ½áÊøÁËÂ𣿠40+3 ССÊ鳿c 2026-07-14 9/450 2026-07-15 16:04 by °²¾²µÄÖªÁË
[»ù½ðÉêÇë] ¹ú×ÔÈ»ÃæÉÏD¿ÚÆíµ» +4 monkeynana 2026-07-14 4/200 2026-07-15 09:14 by °×Ë®Öó
[»ù½ðÉêÇë] ûÊÕµ½ÏûÏ¢£¬ÔÙ´ÎÅãÅÜ +3 Ìì¿ÕÐdz½fly 2026-07-14 3/150 2026-07-14 19:14 by 6543yes
[»ù½ðÉêÇë] Ã÷ÌìE¿ÚÃæÉÏ»áÆÀ +8 ²¼²¼ºÍÒ»¶þ 2026-07-12 9/450 2026-07-13 22:59 by QTSorange
ÐÅÏ¢Ìáʾ
ÇëÌî´¦ÀíÒâ¼û