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µÂ¹úÓ¦»¯Angewandte Chemie International EditionÉÏз¢±íһƪ¹ØÓÚ²ÄÁϱíÃæ¿¹µ°°×Îü¸½µÄ×ÛÊö£¬²¢ÇÒ·âÃæÍÆ¼ö¡£ Protein Interactions with Polymer Coatings and Biomaterials DOI: 10.1002/anie.201400546 ÕýÎÄ http://onlinelibrary.wiley.com/d ... .201400546/abstract ·âÃæ http://onlinelibrary.wiley.com/d ... .201406350/abstract ´ËÎÄΪFreie Universitt Berlin£¬Helmholtz-Zentrum Berlin£¬Helmholtz-Zentrum BerlinÖÐÈý¸öÏà¹ØÁìÓò´ó×éºÏд СÃÃ×ö´ËÁìÓò¹¤×÷£¬¸ÕºÃ¶Áµ½ÕâÆªÎÄÕ£¬¾õµÃÕâÆª×ÛÊöºÜ¶Àµ½£¬²»½ö½ö×ÛÊöÁ˲ÄÁÏ·½ÃæÐ½øÕ¹£¬»¹´Ó»úÀí£¬Ä£Ä⣬·ÖÎö±íÕ÷£¬Ó¦Óõȶ෽λ̽ÌÖµ°°×Îü¸½ÎÊÌ⣬ÔÚ´ËÔ¸½«ºÃÎÄÓë¹Ø×¢´ËÁìÓòµÄ³æÓÑÒ»Æð·ÖÏí¡£ ´ËÎĵÚÒ»²¿·ÖIntroduction£¬Ö÷Òª½éÉܵ°°×Îü¸½»úÀí£¬ÆäÖÐÌáµ½ÁËWhitesides rulesºÍBergs lawµÄ¾ÖÏÞÐÔÓëз¢Õ¹£¬²¢¶ÔÖ¸µ¼¿¹µ°°×Îü¸½²ÄÁÏÉè¼ÆµÄWhitesides rules½øÐÐÁËÐÂÚ¹ÊÍ¡£ µÚ¶þ²¿·ÖMethods for the Analysis of Protein Interactions£¬½éÉÜÁËĿǰ±íÕ÷µ°°×Îü¸½µÄ³£Ó÷½·¨£¬¶ÔһЩз½·¨QCM¡¢SPR¡¢ToF-SIMS¡¢ITC¡¢FTIRµÈ½øÐÐÁËÏêϸ½éÉÜ£¬´ËÍâÏêÊöÁËÉú»¯±íÕ÷ÊֶκͼÆËã»úÄ£Äâ·½·¨¡£ µÚÈý²¿·ÖBioinert and Biospecific Surfaces-Recent Developments and Applications£¬×ÅÖØ½éÉÜ¿¹µ°°×Îü¸½²ÄÁϵÄÑо¿Ð½øÕ¹¼°ÆäÓ¦Óᣲ»Í¬ÓÚÆäËû´ó²¿·Ö´ËÁìÓò×ÛÊö°´²ÄÁÏ·ÖÀà½éÉÜ£¬´ËÎÄ´Ócoating½á¹¹×ÅÊÖ£¬ÌÖÂÛÁ˲»Í¬coatingÐÎʽµÄÀû±×£¬²¢ÇÒÔÚµÚ20Ò³ÓÐÒ»¶ÎרÃŵÄGuidelines for the Design of a Protein-Resistant Surface Coating¡£ µÚËIJ¿·ÖConclusions and Future Perspectives£¬Õ¹ÍûÁË¿¹µ°°×Îü¸½Ñо¿ÖеÄÐÂÎÊÌâºÍ·¢Õ¹·½Ïò¡£Óм¸¸öÎÊÌâÌáµÃºÜ¶Àµ½£¬±ÈÈçÔ½À´Ô½¶àµÄÑо¿Éè¼Æµ½µ°°×¹¹Ïó±ä»¯£¬µ«µ°°×¹¹Ïó±ä»¯¶ÔÉúÎïÏàÈÝÐÔµÄÓ°Ï컹Ñо¿ÉõÉÙ¡£ ÕªÒª Protein adsorption is considered to be the most important factor of the interaction between polymeric biomaterials and body fluids or tissues. Water-mediated hydrophobic and hydration forces as well as electrostatic interactions are believed to be the major factors of protein adsorption. A systematic analysis of various monolayer systems has resulted in general guidelines, the so-called ¡°Whitesides rules¡±. These concepts have been successfully applied for designing various proteinresistant surfaces and are being studied to expand the understanding of protein¨Cmaterial interactions beyond existing limitations. Theories on the mechanisms of protein adsorption are constantly being improved due to the fast-developing analytical technologies. This Review is aimed at improving these empirical guidelines with regard to present theoretical and analytical advances. Current analytical methods to test mechanistic hypotheses and theories of protein¨Csurface interactions will be discussed. Special focus will be given to state-of-the-art bioinert and biospecific coatings and their applications in biomedicine. ×îºó£¬¸½ÉÏÈ«ÎÄ£¬Ï£Íû¶Ô´ó¼ÒÓаïÖú×îÖÕ°æµÄÎÄÕÂÒѾÉÏ´«£¬¸½¼þÀï´øÒ³ÂëÄǸö¡£[ Last edited by Hanawishywo on 2014-7-31 at 04:32 ] |
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