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Hanawishywo

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[资源] 论文推荐：Angew Chem（德国应化）最新蛋白吸附综述（封面推荐）

德国应化Angewandte Chemie International Edition上新发表一篇关于材料表面抗蛋白吸附的综述，并且封面推荐。
Protein Interactions with Polymer Coatings and Biomaterials
DOI: 10.1002/anie.201400546
正文
http://onlinelibrary.wiley.com/d ... .201400546/abstract
封面
http://onlinelibrary.wiley.com/d ... .201406350/abstract

此文为Freie Universitt Berlin，Helmholtz-Zentrum Berlin，Helmholtz-Zentrum Berlin中三个相关领域大组合写

小妹做此领域工作，刚好读到这篇文章，觉得这篇综述很独到，不仅仅综述了材料方面新进展，还从机理，模拟，分析表征，应用等多方位探讨蛋白吸附问题，在此愿将好文与关注此领域的虫友一起分享。

此文第一部分Introduction，主要介绍蛋白吸附机理，其中提到了Whitesides rules和Bergs law的局限性与新发展，并对指导抗蛋白吸附材料设计的Whitesides rules进行了新诠释。
第二部分Methods for the Analysis of Protein Interactions，介绍了目前表征蛋白吸附的常用方法，对一些新方法QCM、SPR、ToF-SIMS、ITC、FTIR等进行了详细介绍，此外详述了生化表征手段和计算机模拟方法。
第三部分Bioinert and Biospecific Surfaces-Recent Developments and Applications，着重介绍抗蛋白吸附材料的研究新进展及其应用。不同于其他大部分此领域综述按材料分类介绍，此文从coating结构着手，讨论了不同coating形式的利弊，并且在第20页有一段专门的Guidelines for the Design of a Protein-Resistant Surface Coating。
第四部分Conclusions and Future Perspectives，展望了抗蛋白吸附研究中的新问题和发展方向。有几个问题提得很独到，比如越来越多的研究设计到蛋白构象变化，但蛋白构象变化对生物相容性的影响还研究甚少。

摘要
Protein adsorption is considered to be the most important factor of the interaction between polymeric biomaterials and body fluids or tissues. Water-mediated hydrophobic and hydration forces as well as electrostatic interactions are believed to be the major factors of protein adsorption. A systematic analysis of various monolayer systems has resulted in general guidelines, the so-called “Whitesides rules”. These concepts have been successfully applied for designing various proteinresistant surfaces and are being studied to expand the understanding of protein–material interactions beyond existing limitations. Theories on the mechanisms of protein adsorption are constantly being improved due to the fast-developing analytical technologies. This Review is aimed at improving these empirical guidelines with regard to present theoretical and analytical advances. Current analytical methods to test mechanistic hypotheses and theories of protein–surface interactions will be discussed. Special focus will be given to state-of-the-art bioinert and biospecific coatings and their applications in biomedicine.

最后，附上全文，希望对大家有帮助
最终版的文章已经上传，附件里带页码那个。[ Last edited by Hanawishywo on 2014-7-31 at 04:34 ]

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附件 1 : 2014_Angew_Review_Protein_Interactions_with_Polymer_Coatings_and_Biomaterials.pdf

2014-07-22 18:42:20, 5.31 M