| 查看: 1524 | 回复: 9 | |||||
| 当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖 | |||||
laozhuangzi铜虫 (正式写手)
|
[交流]
New Trends in Enzyme Catalysis and Biomimetic Chemical Reactions 已有3人参与
|
||||
|
About two centuries ago the German poet, writer and philosopher J.W. Goethe noted that Nature is not only a great artist but also a skillful master. The contemporary generation of scientists who work in the fields of molecular biology, biochemistry and biophysics can appreciate to the fullest extent not only the internal beauty of natural molecular structures but also with what consummate skill these structures have been created. One of the wonderful creations of Nature, biological catalysis, appears as a challenging problem to chemists of the 21th century. The unique catalytic properties of enzyme, which are their precise specificity, selectivity, high rate of chemical reaction, and regulatory capacity occupy a great deal of attention. Classical and modern physical chemistry, chemical kinetics, organic, inorganic and quantum-chemistry provide an arsenal of physical methods and establish a basis for the investigation of structure and action mechanism of enzymes. The general properties of enzymes, the “ideal” chemical catalysts, are the formation of intermediates, smooth thermodynamic relief along the reaction coordinate, fulfillment of all selection rules for chemical reactions, the ability to proceed and to stop temporarily and spatially, and compatibility with the ambient media. These properties are possible by multifunctional active centers, by the unique structure of protein globules, possessing both rigidity and flexibility, and the formation of catalytic ensembles. Biochemistry returns to chemistry a plethora of knowledge about nearly “ideal” catalysts and opens the way for chemical modeling of enzyme reactions. This book is a view of enzyme catalysis by a physico-chemist with long-term experience in the investigation of structure and action mechanism of biological catalysts. This book is not intended to provide an exhaustive survey of each topic but rather a discussion of their theoretical and experimental background, and recent developments. The literature of enzyme catalysis is so vast and many scientists have made important contribution in the area, that it is impossible in the space allowed for this book to give a representative set of references. The author has tried to use reviews, and general principles of articles. He apologizes to those he has not been able to include. The first chapter of the present monograph expound upon new approaches and twists to traditional physical and kinetic methods of investigation of structure and action mechanism. The second chapter is a brief outline of current ideas on the general mechanisms of separate stages of enzyme catalytic processes. In the subsequent chapters, the author’s attention focuses on an analysis of structure and action mechanism of “tough” enzymatic processes which can not yet be effectively realized by chemists in ambient conditions: reduction of nitrogen, hydroxylation of alkans, conversion of light energy, photosynthetic water oxidation; etc. The present status of the knowledge of protein molecular dynamics (fluctuation dynamics of protein) and its paramount role in enzyme functions will be reviewed. Areas related to enzyme catalysis such as antibody catalysis, enzymes in organic solvents, enzymes in synthetic chemistry and enzyme design are outlined. In concluding chapter, a progress in chemical mimicking of “tough” enzymatic reactions is considered. |
回复此楼» 本帖附件资源列表
-
欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com - 附件 1 : New_Trends_in_Enzyme_Cata(BookZZ.org).pdf
2014-07-15 16:16:39, 4.3 M
» 收录本帖的淘帖专辑推荐
 专业电子书 | 生物化学和分子生物学 |
» 本帖已获得的红花（最新10朵）
louiexp» 猜你喜欢
生物学学硕求调剂
已经有10人回复
-
上海电力大学材料防护与新材料重点实验室招收调剂研究生（材料、化学、电化学，环境）
已经有4人回复
-
材料学求调剂
已经有6人回复
-
303求调剂
已经有5人回复
-
一志愿武理085500机械专业总分300求调剂
已经有7人回复
-
考研调剂
已经有4人回复
-
281求调剂
已经有4人回复
-
0805 316求调剂
已经有6人回复
-
085601求调剂总分293英一数二
已经有3人回复
-
08工学调剂
已经有17人回复
0.8
| 顶一下，感谢分享！ |
7楼2014-07-20 15:29:28
0.8
| 顶一下，感谢分享！ |
2楼2014-07-15 18:18:02
0.8
| 顶一下，感谢分享！ |
3楼2014-07-16 22:26:20
0.8
| 顶一下，感谢分享！ |
4楼2014-07-17 03:47:11
5