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Study on potential antitumor mechanism of quinoline-based silver(I) complexes: Synthesis, structural characterization, cytotoxicity, cell cycle and caspase-initiated apoptosis Yu-Lan Li a, Qi-Pin Qina, Yun-Feng An , Yan-Cheng Liu , Guo-Bao Huang , Xu-Jian Luo Guo-Hai Zhang |
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baiyuefei
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2楼2014-07-01 16:32:22
baiyuefei
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Study on potential antitumor mechanism of quinoline-based silver(I) complexes: Synthesis, structural characterization, cytotoxicity, cell cycle and caspase-initiated apoptosis 作者:Li, YL (Li, Yu-Lan)[ 1 ] ; Qin, QP (Qin, Qi-Pin)[ 1 ] ; An, YF (An, Yun-Feng)[ 1 ] ; Liu, YC (Liu, Yan-Cheng)[ 1 ] ; Huang, GB (Huang, Guo-Bao)[ 1 ] ; Luo, XJ (Luo, Xu-Jian)[ 2,3 ] ; Zhang, GH (Zhang, Guo-Hai)[ 1 ] INORGANIC CHEMISTRY COMMUNICATIONS 卷: 40 页: 73-77 DOI: 10.1016/j.inoche.2013.11.014 出版年: FEB 2014 查看期刊信息 摘要 Three mononuclear silver(I) complexes with 8-hydroxyquinoline, 8-hydroxy-2-methylquinoline and 5-chloro-8-quinolinol were synthesized and characterized by elemental analysis, NMR, ESI-MS as well as single crystal X-ray diffraction analysis. All the structures of complexes 1-3 with the silver center adopting an approximately four-coordinated distorted tetragonal pyramid geometry were found to exhibit selective cytotoxicity against HepG2, NCI-H460, BEL-7404 and HeLa cell lines with IC50 values generally in the micromolar range (1.7-14.6 mu M), but low cytotoxicity towards normal human liver cell HL-7702. A combination of flow cytometric analysis and molecular probe observation indicated that complexes 1-3 could induce HepG2 cell apoptosis. Molecular mechanism studies suggested that complexes 1-3-induced apoptosis is mediated through the intrinsic apoptotic pathway with changes in mitochondrial membrane potential by finally activating effector caspase-3/9 to trigger cell apoptosis. Further studies revealed that complexes 1 and 2 caused cell cycle arrest at S phase, while complex 3 induced G1 cell cycle arrest in HepG2 cells. Taken together, these results suggest that complexes 1-3 may be potential candidates for cancer therapy. (C) 2013 Elsevier B.V. All rights reserved. 关键词 作者关键词:Quinoline-based; Silver(I) complexes; Cytotoxicity; Cell cycle; Apoptosis; Anticancer activity KeyWords Plus  NA-CLEAVAGE 作者信息 通讯作者地址: Zhang, GH (通讯作者) Guangxi Normal Univ, Sch Pharm & Chem, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China. 地址: [ 1 ] Guangxi Normal Univ, Sch Pharm & Chem, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China [ 2 ] Cent S Univ, Coll Chem & Chem Engn, Changsha 410083, Hunan, Peoples R China [ 3 ] Yulin Normal Univ, Coll Chem & Mat, Yulin 537000, Peoples R China 电子邮件地址:lxj408@126.com; zgh408@126.com 基金资助致谢 基金资助机构 授权号 Natural Science Foundation of Guangxi Province 2013GXNSFBA019159 2013GXNSFBA019200 Guangxi Pharmaceutical Industry Talent Small Highland Project 1309 1312 Foundation of State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China as Bagui Scholar Program of Guangxi, China CMEMR2012-A12 CMEMR2013-A IRT1225 查看基金资助信息 出版商 ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS 类别 / 分类 研究方向:Chemistry Web of Science 类别:Chemistry, Inorganic & Nuclear 文献信息 文献类型:Article 语种:English 入藏号: WOS:000331506600020 ISSN: 1387-7003 电子 ISSN: 1879-0259 期刊信息 Impact Factor (影响因子): Journal Citation Reports® 其他信息 IDS 号: AB0UC Web of Science 核心合集中的 "引用的参考文献": 21 Web of Science 核心合集中的 "被引频次": 0 |
3楼2014-07-01 16:32:36