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×÷Õß: Cui BC1, Yoon I2, Li JZ3, Lee WK4, Shim YK5. ÎÄÌâ: Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy. ÆÚ¿¯Ãû,Äê·Ý,¾í(ÆÚ),ÆðÖ¹Ò³Âë: Int J Mol Sci. 2014 May 8;15(5):8091-105. doi: 10.3390/ijms15058091. ÊÕ¼ÐÅÏ¢: Çë°ïæ²ésciÊÕ¼ºÅÊÇ·ñÒѳö£¡ |
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Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy. ×÷Õß:Cui, Bing Cun; Yoon, Il; Li, Jia Zhu; Lee, Woo Kyoung; Shim, Young Key International journal of molecular sciences ¾í:15 ÆÚ:5 Ò³:8091-105 DOI:10.3390/ijms15058091 ³ö°æÄê:2014 May 08 ÕªÒª A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers. ×÷ÕßÐÅÏ¢ µØÖ·:College of Medicine, Hubei Polytechnic University, Huangshi 435003, China. cuibc928@hotmail.com. ÎÄÏ×ÐÅÏ¢ ÎÄÏ×ÀàÐÍ:Journal Article; Research Support, Non-U.S. Gov't ÓïÖÖ:English PubMed ID:24815070 NLM Ψһ ID:101092791 ´´½¨ÈÕÆÚ: 12 May 2014 µç×Ó³ö°æ:08 May 2014 ¹ú¼Ò/µØÇø: Switzerland ISSN:1422-0067 ÆÚ¿¯ÐÅÏ¢ Impact Factor (Ó°ÏìÒò×Ó): Journal Citation Reports® ÆäËûÐÅÏ¢ ·ÖÖ÷Ìâ×Ó¿â:Index Medicus ״̬:In-Process |
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