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[交流] 征集收载多个溶出度方法的制剂

如题。
例如，SUP 左乙拉西坦片收载有3种溶出度方法。

回帖方式：
品种：***
药典：USP、EP等

速释一个品种10个金币，缓释一个品种5个金币
多劳多得。希望大家踊跃参与。
金币不是问题，不够会增加的。

[ Last edited by News on 2014-6-24 at 10:45 ]

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DRDEPI: 6
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盐酸普鲁卡因胺片 USP
第一法：Medium: 0.1 N hydrochloric acid; 900 mL.
         Apparatus 2: 50 rpm.
         Times: 1（30%~60%）, 4（60%~90%）, and 6 hours.（≥75%）
第二法：ACID STAGE: 0.1 N hydrochloric acid; 900 mL for 1 hour.
      BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 900 mL (see Buffer Solutions under Reagents, Indicators, and Solutions) for not less than 8 hours.
      Apparatus 2: 50 rpm, with sinkers.
      Times: 1（30%~60%）, 4（60%~90%）, and 8 hours（≥80%）.
第三法：Medium—Proceed as directed under Test 2.
         Apparatus 2: 50 rpm, with sinkers.
         Times: 1（25%~50%）, 3（40%~75%）, 6（65%~90%）, and 8 hours（≥80%）
第四法 Medium: 0.1 N hydrochloric acid; 900 mL.
         Apparatus 1: 50 rpm.
         Times: 1（≤30%）, 2（25%~45%）, 4（45%~75%）, 8（70%~90%）, and 14 hours（≥80%）.
第五法：Medium— Proceed as directed for Method B under Delayed Release Dosage Forms.
         ACID STAGE: 0.1 N hydrochloric acid; 1000 mL for 1 hour.
         BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 1000 mL (see Buffer Solutions under Reagents, Indicators, and Solutions) for not  less than 8 hours.
         Apparatus 2: 50 rpm, with sinkers                                                                      500mg规格 Times: 1（30%~45%）, 4（55%~75%）, 6（≥65%）, and 8 hours.（≥75%）
750mg与1000mg规格片剂： Times: 1（30%~50%）, 4（60%~80%）, 6（70%~90%）, and 8 hours.（≥75%）

第六法：Medium—Proceed as directed for Test 2.
         Apparatus 2: 50 rpm.
         Times: 1, 4, and 8 hours.
         规格不同，溶出标准也有不同
第七法：Medium— Proceed as directed for Method B under Delayed- Release Dosage Forms.
         ACID STAGE: 0.1 N hydrochloric acid; 900 mL for 1 hour.
      BUFFER STAGE: 0.05 M phosphate buffer, pH 7.5; 900 mL (see the Buffer Solutions under Reagents, Indicators, and Solutions) for not  less than 8 hours.
Apparatus 2: 50 rpm, with sinkers. .
Times: 1, 4, 6, and 8 hours.
Procedure—Proceed as directed for Procedure in Test 1.
Tolerances—Proceed as directed for Tolerances in Test 2.