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ÊéÃû Advances in Immunology 121¾í
×÷ÕßK. Frank Austen
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ISBN: 978-0-12-800100-4
ISSN: 0065-2776
Ŀ¼1. Introduction 2
2. Ligand¨CReceptor Complex Formation: Geometry and Affinity 3
2.1 Surface receptor complex geometry and signal activation 4
2.2 Ligand¨Creceptor affinity: Stability of the ternary complex 8
2.3 Ligand¨Creceptor affinity: Kinetics of complex formation 12
3. Receptor Dynamics and Endosomal Trafficking 14
4. Intracellular Protein Levels and Signaling Activation 19
4.1 Jaks and receptor expression and affinity 20
4.2 Crosstalk between STATs 20
5. Tuning Cytokine Signaling via Protein Engineering 23
5.1 Modulation of trafficking: IL-2 and EGF 24
5.2 Modulation of ligand affinity and activities: IFN and IL-3 25
5.3 Increasing ligand specificity: IL-2 and IL-4 26
6. Perspectives 28
Acknowledgments 29
References 29
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