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The major component of berberine from Coptis chinensis possesses variety of pharmacological activity, including neurodegenerative diseases with Alzheimer¡¯s disease (AD) treatment. Therapeutic effect of berberine was known by inhibiting the relevant enzyme and amino acid to prevent (AD) disease. Unfortunately, the single of berberine compound in regulation of those has not significantly materialized. In order for us to consider in the section, the review paper to investigation in based structured by chemically modified and synthesis from berberine-derivatives. Results showed the potential effect in based structures of (23), (10), (86), (52), and (61) for the first time.
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YauYau: ½ð±Ò+20, ·­ÒëEPI+1, ¡ï¡ï¡ï¡ï¡ï×î¼Ñ´ð°¸, Thank you so much again! 2014-06-09 00:21:34
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The main components of berberine separated from coptis have a variety of pharmacological activity which include the treatment component of neurodegenerative diseases, Alzheimer's disease (AD). The principle of berberine is inhibiting the lower activity of related enzymes and amino acids to prevent Alzheimer's disease (AD), which is well-known to us.  However, the single chemical structures of berberine  is of no significance to regulation effect. As a part of our consideration, this review article studies on the chemical synthesis and modification of the infrastructure of the berberine's derivatives. The results show that the structures of (23), (10), (86), (52), and (61) have a potential effect  to the infrastructure at the first time.
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