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作者:
Cui BC1, Yoon I2, Li JZ3, Lee WK4, Shim YK5.
文题:
Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.
期刊名,年份,卷(期),起止页码:
Int J Mol Sci. 2014 May 8;15(5):8091-105. doi: 10.3390/ijms15058091.
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Synthesis and characterization of novel purpurinimides as photosensitizers for photodynamic therapy.


作者:Cui, Bing Cun; Yoon, Il; Li, Jia Zhu; Lee, Woo Kyoung; Shim, Young Key




International journal of molecular sciences



卷:15

期:5

页:8091-105

DOI:10.3390/ijms15058091

出版年:2014 May 08


摘要



A series of novel purpurinimides with long wavelength absorption were designed and synthesized to develop novel and potential photosensitizers. These compounds were investigated through reduction, oxidation, rearrangement reaction and amidation reactions of methyl pheophorbide a. They demonstrated a considerable bathochromic shift of the major absorption band in the red region of the optical spectrum (695-704 nm). Newly synthesized purpurinimides were screened for their antitumor activities, and showed higher photodynamic efficiency against A549 cell lines as compared to purpurin-18 methyl ester. The results revealed the novel purpurinimides could be potential photosensitizers.



作者信息

地址:College of Medicine, Hubei Polytechnic University, Huangshi 435003, China. cuibc928@hotmail.com.


文献信息

文献类型:Journal Article

语种:English

PubMed ID:24815070

NLM 唯一 ID:101092791

创建日期:  12 May 2014         

电子出版:08 May 2014

国家/地区: Switzerland

ISSN:1422-0067


期刊信息


Impact Factor (影响因子):  Journal Citation Reports®


  

其他信息

分主题子库:Index Medicus

状态:In-Data-Review
   

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