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This is paradoxical, however. One would expect that destroying the vasculature would severely compromise the delivery of oxygen and therapeutics to the solid tumor, producing hypoxia that would render many chemotherapeutics, as well as radiation, less effective.Indeed, some studies show that antiangiogenic therapy can compromise the delivery of drugs to tumors, as well as antagonize the outcome of radiation therapy . How can we reconcile these diametrically opposed outcomes of combination therapy with the positive preclinical and clinical data? The answer to this question is critical for optimizing the efficacy of combined antiangiogenic and cytotoxic therapy. |
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