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cainiaodui新虫 (小有名气)
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| The physiological changes described have a direct effect on solid tumor behavior. Hypoxic tumor cells often show a more aggressive phenotype, activating oncogenes and passing through an “epithelial to mesenchymal transition” (EMT), which heightens their metastatic potential. Moreover, the hostile microenvironment impairs the function of antitumor immune cells, the delivery of which into the tumor is also impaired. Importantly, tumor response to therapy is also impacted. Hypoxia is known to reduce tumor cell sensitivity to radiation and chemotherapy ,and the delivery of systemically administered cytotoxics into tumors is dramatically impeded, especially in areas of low blood flow and raised tumor IFP. It is thus clear that tumor angiogenesis fuels a cascade of microenvironmental abnormalities which can hinder therapeutic outcomes. Reversal of these abnormalities, achieved through “normalizing” tumor vessels, is therefore an intuitively attractive proposition. |
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shiranjiang
金虫 (正式写手)
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真强必胜: 金币+1, 谢谢 2014-05-11 17:03:19
cainiaodui(RXMCDM代发): 金币+5 2014-06-08 00:03:48
真强必胜: 金币+1, 谢谢 2014-05-11 17:03:19
cainiaodui(RXMCDM代发): 金币+5 2014-06-08 00:03:48
| 所描述的生理变化对实体瘤的行为有直接的影响。缺氧的肿瘤细胞通过激活癌基因和经过上皮-间质转化(EMT)提高其转移的潜力后往往表现出更积极的表型。此外，敌对的微环境会损害抗肿瘤免疫细胞的功能，使进入肿瘤的传递受损。重要的是,肿瘤的治疗也会受到影响。缺氧降低了肿瘤细胞对放疗与化疗的敏感性,尤其是在血流量低和肿瘤组织间隙液压升高的区域，对系统性执行的细胞毒素进入肿瘤的传递造成极大的阻碍。由此可见，肿瘤血管生成可导致大量的影响治疗结果的微环境异常，因此，通过“正常化”肿瘤血管来逆转这些异常是一个具有直观吸引力的话题。 |
2楼2014-05-11 14:41:40