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cainiaodui新虫 (小有名气)
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| The physiological changes described have a direct effect on solid tumor behavior. Hypoxic tumor cells often show a more aggressive phenotype, activating oncogenes and passing through an “epithelial to mesenchymal transition” (EMT), which heightens their metastatic potential. Moreover, the hostile microenvironment impairs the function of antitumor immune cells, the delivery of which into the tumor is also impaired. Importantly, tumor response to therapy is also impacted. Hypoxia is known to reduce tumor cell sensitivity to radiation and chemotherapy ,and the delivery of systemically administered cytotoxics into tumors is dramatically impeded, especially in areas of low blood flow and raised tumor IFP. It is thus clear that tumor angiogenesis fuels a cascade of microenvironmental abnormalities which can hinder therapeutic outcomes. Reversal of these abnormalities, achieved through “normalizing” tumor vessels, is therefore an intuitively attractive proposition. |
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shiranjiang
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【答案】应助回帖
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真强必胜: 金币+1, 谢谢 2014-05-11 17:03:19
cainiaodui(RXMCDM代发): 金币+5 2014-06-08 00:03:48
真强必胜: 金币+1, 谢谢 2014-05-11 17:03:19
cainiaodui(RXMCDM代发): 金币+5 2014-06-08 00:03:48