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±¾ÎĵÄÂ×ÀíµÀµÂÉùÃ÷£º All animal experiments were approved by Care and Use of Animals Center, #### University. This study was carried out in strict accordance with the Guidelines for the Care and Use of Animals of #### University. Every effort was made to minimize animal pain, suffering and distress and to reduce the number of animal used. All participants were informed of the purposes of the study and the risks associated with the procedures. Written informed consent was obtained from all participants before the study commenced. PLOS ONE±à¼ÈÃÐ޸ĵĻØÐÅ£º Dear Dr. Zhang, Thank you for submitting your manuscript entitled "######" to PLoS ONE. Your manuscript files have been checked in house but before we can proceed, we need you to address the following issues: 1, Thank you for amending your ethics statement to : "All animal experiments were approved by Care and Use of Animals Center, #### University. This study was carried out in strict accordance with the Guidelines for the Care and Use of Animals of #### University. Every effort was made to minimize animal pain, suffering and distress and to reduce the number of animal used. All participants were informed of the purposes of the study and the risks associated with the procedures. Written informed consent was obtained from all participants before the study commenced." We are happy with the animal ethics, you have stated human consent, For studies reporting research involving human participants if this is the case, PLOS ONE requires authors to confirm that the study was reviewed and approved by an institutional review board (ethics committee) before the study began. Please provide the specific name of the ethics committee/IRB that approved your study, or explain why you did not seek approval in this case. Once you have amended this/these statement(s) in the Methods section of the manuscript, please add the same text to the ¡°Ethics Statement¡± field of the submission form (via ¡°Edit Submission¡±). For additional information about PLOS ONE ethical requirements for human subjects research, please refer to http://www.PLOSone.org/static/guidelines.action#human. Your manuscript has been returned to your account. Please log on to PLOS Editorial Manager at http://pone.edmgr.com/ to access your manuscript. Your manuscript can be found in the "Submissions Sent Back to Author" link under the New Submissions menu. After you have made the changes requested above, please be sure to view and approve the revised PDF after rebuilding the PDF to complete the resubmission process. Please note that these changes have been requested to comply with submission guidelines and your manuscript will *not* be sent to review until you have fully adhered to our requests. Once your paper has been seen by an Editor we may return it to you for further information or amendments. Thank you for submitting your work to PLOS ONE. Kind regards, Julie Coleman PLOS ONE ¸ÃÎÄÕÂÊÇ´óÐÞ£¬Ö»ÊÇÂ×ÀíµÀµÂÕâÒ»ÏîÒѾÐ޸ĹýÁ½´Î»¹ÊDz»´ï±ê£¬°´Õձ༵ÄÒâ˼ÊÇҪʲô¹Ù·½ÎļþÂð£¿Çë´óÉñ¸øÒ»¸öÄÜÖ±½Ó½â¾öµÄ°ì·¨£¬Ìû×ÓÉϵÄÂ×ÀíµÀµÂÉùÃ÷ÊÇ·ÂÕÕÒ»¸öʦÐÖÈ¥Äê·¢µÄÎÄÕÂдµÃ£¬½ñÄê¾Í²»ÐÐÁË£¬ÓôÃÆ°¡¡£ |
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