24小时热门版块排行榜

南方科技大学公共卫生及应急管理学院2025级博士研究生招生报考通知

返回列表

【奖励】本帖被评价17次，作者liujieqing增加金币 13 个

当前只显示满足指定条件的回帖，点击这里查看本话题的所有回帖

liujieqing

铁虫 (著名写手)

应助: 0 (幼儿园)
金币: 5157.9
帖子: 1377
在线: 238小时
虫号: 110922

[资源] 合成与植物化学结合的方向Diversity-Oriented Synthesis

The gap between insights into human disease and therapeutics that arise from these
insights is closing, but it cannot close fast enough. Society has patiently invested in
science. But its expectation of scientists—that we mitigate suffering from disease—
must be met if we expect to receive its support in the future.
Advances in human biology are revealing novel insights into the cause of disease
and requirements for the maintenance of disease. But the therapeutic targets that are
arising, such as transcription factors and RNA molecules, do not fit conveniently
into what we believe is currently achievable in drug discovery. Overcoming this
belief is the twenty-first century challenge for organic chemistry, organic synthesis,
and chemical biology. If we can do so, drug discovery and human health will be
transformed.
The insights provided in Diversity-Oriented Synthesis: Basics and Applications
in Organic Synthesis, Drug Discovery, and Chemical Biology leave me feeling optimistic.
I can sense the fearlessness and audacity of the authors as they undertake
the impossible. The three-dimensional world of biological macromolecules is now
interfaced with the three-dimensional world of small molecules to a far greater
degree. Therapeutic targets are now seeing the full force of modern organic chemistry.
Using simple concepts exploited by nature’s synthesis of naturally occurring
small molecules, small molecules with the physical properties required of drugs
yet with the topographic properties needed for achieving the impossible are now
accessible. Bravo!
Stuart L. Schreiber

回复此楼

» 本帖附件资源列表

欢迎监督和反馈：小木虫仅提供交流平台，不对该内容负责。
本内容由用户自主发布，如果其内容涉及到知识产权问题，其责任在于用户本人，如对版权有异议，请联系邮箱：xiaomuchong@tal.com
附件 1 : Diversity-Oriented_Synthesis,_Basics_and_Applications_in_Organic_Synthesis,_Drug_Discovery,_and_Chemical_Biology.pdf

2014-03-27 09:30:06, 20.72 M